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Cytoskeletal filament systems: assembly, regulation, and interplay in mammalian cells
Umeå universitet, Institutionen för molekylärbiologi (Medicinska fakulteten).
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The cell represents the basic unit of structure and function for all life. The interior of a eukaryotic cell is organized by an extensive array of protein filaments – collectively referred to as the cytoskeleton. These filaments serve diverse essential functions, e.g. to provide mechanical resilience, facilitate intracellular transport, and enable cell polarization, locomotion and division. Here I have explored the mechanisms that regulate synthesis and assembly of two cytoskeletal filament systems – microtubules and septins – and how these interact in human cells. The present thesis is based on three principal discoveries. Firstly, we have found that the microtubule-destabilizing protein Op18/Stathmin also regulates synthesis of tubulin heterodimers, which are the building blocks for microtubules. Secondly, we have unraveled the general rules that govern assembly of mammalian septins into native polymerization-competent heterooligomers. Finally, our combined results point to a non-reciprocal interplay whereby interphase microtubules support a disc-like arrangement of septin filaments, which delineate static plasma membrane regions. I here discuss the physiological significance and implications of these findings.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, Institutionen för molekylärbiologi , 2011. , 68 p.
National Category
Cell and Molecular Biology
Research subject
cellforskning
Identifiers
URN: urn:nbn:se:uu:diva-310053ISBN: 9789174593013 (print)OAI: oai:DiVA.org:uu-310053DiVA: diva2:1054780
Public defence
2011-11-11, Major Groove, Institutionen för Molekylärbiologi, Försörjningsvägen, 09:00 (English)
Opponent
Supervisors
Available from: 2011-10-21 Created: 2016-12-09 Last updated: 2016-12-09

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