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Prognostic Implications of 2005 Gleason Grade Modification. Population-Based Study of Biochemical Recurrence Following Radical Prostatectomy
Univ Copenhagen, Rigshosp, Copenhagen Prostate Canc Ctr, Copenhagen, Denmark.;Univ Copenhagen, Rigshosp, Dept Urol, Copenhagen, Denmark..
Univ Uppsala Hosp, Reg Canc Ctr, Uppsala, Sweden..
Univ Copenhagen, Rigshosp, Copenhagen Prostate Canc Ctr, Copenhagen, Denmark.;Univ Copenhagen, Rigshosp, Dept Urol, Copenhagen, Denmark..
NYU, Dept Urol, Populat Hlth, New York, NY USA.;NYU, Laura & Isaac Perlmutter Canc Inst, New York, NY USA.;Manhattan Vet Affairs Med Ctr, New York, NY USA..
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2016 (English)In: Journal of Surgical Oncology, ISSN 0022-4790, E-ISSN 1096-9098, Vol. 114, no 6, 664-670 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To assess the impact of the 2005 modification of the Gleason classification on risk of biochemical recurrence (BCR) after radical prostatectomy (RP). Patients and Methods: In the Prostate Cancer data Base Sweden (PCBaSe), 2,574 men assessed with the original Gleason classification and 1,890 men assessed with the modified Gleason classification, diagnosed between 2003 and 2007, underwent primary RP. Histopathology was reported according to the Gleason Grading Groups (GGG): GGG1 = Gleason score (GS) 6, GGG2 = GS 7(3+4), GGG3 = GS 7(4+3), GGG4 = GS 8 and GGG5 = GS 9-10. Cumulative incidence and multivariable Cox proportional hazards regression models were used to assess difference in BCR. Results: The cumulative incidence of BCR was lower using the modified compared to the original classification: GGG2 (16% vs. 23%), GGG3 (21% vs. 35%) and GGG4 (18% vs. 34%), respectively. Risk of BCR was lower for modified versus original classification, GGG2 Hazard ratio (HR) 0.66, (95% CI 0.49-0.88), GGG3 HR 0.57 (95% CI 0.38-0.88) and GGG4 HR 0.53 (95% CI 0.29-0.94). Conclusion: Due to grade migration following the 2005 Gleason modification, outcome after RP are more favourable. Consequently, outcomes from historical studies cannot directly be applied to a contemporary setting.

Place, publisher, year, edition, pages
2016. Vol. 114, no 6, 664-670 p.
Keyword [en]
prostate cancer, radical prostatectomy, biochemical recurrence, Gleason classification, ISUP
National Category
Cancer and Oncology Surgery Urology and Nephrology
Identifiers
URN: urn:nbn:se:uu:diva-309998DOI: 10.1002/jso.24408ISI: 000387032100002PubMedID: 27511833OAI: oai:DiVA.org:uu-309998DiVA: diva2:1055427
Funder
Swedish Research Council, 825-2012-5047Swedish Cancer Society, 130428NIH (National Institute of Health), K07CA178258
Available from: 2016-12-12 Created: 2016-12-09 Last updated: 2016-12-12Bibliographically approved

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Stattin, Pär
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