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Hypertension in adults with repaired coarctation of the aorta
Umea Univ, Ctr Heart, Umea, Sweden.;Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden..
Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden..
Lund Univ, Clin Sci, Dept Cardiol, Lund, Sweden..
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden..
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2016 (English)In: American Heart Journal, ISSN 0002-8703, E-ISSN 1097-6744, Vol. 181, 10-15 p.Article in journal (Refereed) Published
Abstract [en]

Aims: In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN.

Methods and results: In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36.9 +/- 14.4 years); 344 (52.7%) of them had HTN, defined as either an existing diagnosis or blood pressure (BP) >= 140/90 mmHg at the clinical visit. In a multivariable model, age (years) (odds ratio [OR] 1.07, CI 1.05-1.10), sex (male) (OR 3.35, CI 1.98-5.68), and body mass index (kilograms per square meter) (OR 1.09, CI 1.03-1.16) were independently associated with having HTN, and so was systolic arm-leg BP gradient where an association with HTN was found at the ranges of (10, 20] and >20 mmHg, in comparison to the interval <= 10 mmHg (OR 3.58, CI 1.70-7.55, and OR 11.38, CI 4.03-32.11). This model remained valid when all patients who had increased BP (>= 140/90 mmHg) without having been diagnosed with HTN were excluded from the analyses.

Conclusions: Hypertension is common in patients with previously repaired CoA and is associated with increasing age, male sex, and elevated body mass index. There is also an association with arm-leg BP gradient, starting at relatively low levels that are usually not considered for intervention.

Place, publisher, year, edition, pages
2016. Vol. 181, 10-15 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-309814DOI: 10.1016/j.ahj.2016.07.012ISI: 000387253900004PubMedID: 27823680OAI: oai:DiVA.org:uu-309814DiVA: diva2:1056394
Available from: 2016-12-14 Created: 2016-12-07 Last updated: 2016-12-14Bibliographically approved

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