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Clinical efficacy and safety of a water-soluble micellar paclitaxel (Paccal Vet) in canine mastocytomas
Swedish Univ Agr Sci SLU, Dept Clin Sci, Ctr Clin Comparat Oncol, SE-75007 Uppsala, Sweden..
Jonkoping Small Anim Hosp, Jonkoping, Sweden..
Djurakuten, Stockholm, Sweden..
Tierklinik, Hofheim, Germany..
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2013 (English)In: Journal of Small Animal Practice, ISSN 0022-4510, E-ISSN 1748-5827, Vol. 54, no 1, 20-27 p.Article in journal (Refereed) Published
Abstract [en]

Objective To determine the clinical efficacy and safety of a cremophor-free formulation of paclitaxel (Paccal Vet, Oasmia Pharmaceuticals) in dogs with mast cell tumours. Methods Paccal Vet was administered at a median dose of 145 (range, 135 to 150) mg/m2intravenously once every 21 days for three cycles to 29 dogs with macroscopic grade 2 or 3 mast cell tumour. Efficacy was assessed by tumour response (Response Evaluation Criteria in Solid Tumours version 1.0) and performance status score. Progression-free survival, quality of life and safety/adverse events were also evaluated. Clinical safety was assessed by clinicopathological analyses and recording of adverse events. Results Complete or partial response was observed in 59% of dogs. Performance status score remained constant or improved for 20 dogs and decreased by one grade for 9 dogs. Median time to progression was 247 (range, 42 to 268) days. Expected, transient frequently subclinical adverse events (primarily grade 3/4 neutropenia and grade 1/2 leukopenia) were observed in the majority of dogs. Nine dogs were euthanased and one dog died due to disease progression. Clinical Significance Paccal Vet appears to be a clinically safe and effective treatment for canine mast cell tumours. Further controlled confirmatory investigation is warranted.

Place, publisher, year, edition, pages
2013. Vol. 54, no 1, 20-27 p.
National Category
Clinical Science
URN: urn:nbn:se:uu:diva-309905DOI: 10.1111/j.1748-5827.2012.01304.xISI: 000312945900005PubMedID: 23190121OAI: oai:DiVA.org:uu-309905DiVA: diva2:1056729
Available from: 2016-12-15 Created: 2016-12-08 Last updated: 2016-12-15Bibliographically approved

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