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inbreedR: an R package for the analysis of inbreeding based on genetic markers
Univ Bielefeld, Dept Anim Behav, Box 100131, Bielefeld, Germany.;Liverpool John Moores Univ, Fac Sci, Sch Nat Sci & Psychol, Liverpool L3 3AF, Merseyside, England..
Univ Bielefeld, Fac Technol, Box 100131, Bielefeld, Germany..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Evolutionary Biology.
Univ Bielefeld, Dept Anim Behav, Box 100131, Bielefeld, Germany.;British Antarctic Survey, Madingley Rd, Cambridge CB3 OET, England..
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2016 (English)In: Methods in Ecology and Evolution, ISSN 2041-210X, E-ISSN 2041-210X, Vol. 7, no 11, 1331-1339 p.Article in journal (Refereed) Published
Abstract [en]

Heterozygosity-fitness correlations (HFCs) have been widely used to explore the impact of inbreeding on individual fitness. Initially, most studies used small panels of microsatellites, but more recently with the advent of next-generation sequencing, large SNP datasets are becoming increasingly available and these provide greater power and precision to quantify the impact of inbreeding on fitness. Despite the popularity of HFC studies, effect sizes tend to be rather small. One reason for this may be low variation in inbreeding levels among individuals. Using genetic markers, it is possible to measure variance in inbreeding through the strength of correlation in heterozygosity across marker loci, termed identity disequilibrium (ID). ID can be quantified using the measure g2, which is also a central parameter in HFC theory that can be used within a wider framework to estimate the direct impact of inbreeding on both marker heterozygosity and fitness. However, no software exists to calculate g2 for large SNP datasets nor to implement this framework. inbreedR is an R package that provides functions to calculate g2 based on microsatellite and SNP markers with associated P-values and confidence intervals. Within the framework of HFC theory, inbreedR also estimates the impact of inbreeding on marker heterozygosity and fitness. Finally, inbreedR implements user-friendly simulations to explore the precision and magnitude of estimates based on different numbers of genetic markers. We hope this package will facilitate good practice in the analysis of HFCs and help to deepen our understanding of inbreeding effects in natural populations.

Place, publisher, year, edition, pages
2016. Vol. 7, no 11, 1331-1339 p.
Keyword [en]
genetic marker, heterozygosity, heterozygosity-fitness correlation (HFC), identity disequilibrium, inbreeding
National Category
Genetics Bioinformatics (Computational Biology)
Identifiers
URN: urn:nbn:se:uu:diva-310773DOI: 10.1111/2041-210X.12588ISI: 000387669600009OAI: oai:DiVA.org:uu-310773DiVA: diva2:1057905
Available from: 2016-12-19 Created: 2016-12-19 Last updated: 2016-12-19Bibliographically approved

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Kardos, Marty
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