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Basal and induced EROD activity in the chorioallantoic membrane during chicken embryo development
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences, Toxicology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolutionary Biology, Environmental Toxicology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolutionary Biology, Environmental Toxicology.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Evolutionary Biology, Environmental Toxicology.
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1999 (English)In: Environmental Toxicology and Pharmacology, ISSN 1382-6689, E-ISSN 1872-7077, Vol. 8, no 1, 49-52 p.Article in journal (Other academic) Published
Abstract [en]

The chorioallantoic membrane (CAM) is a highly vascularized tissue that takes part in the respiratory exchange of gases through the eggshell. Although the CAM may be exposed to environmental contaminants, its response to pollutants has not been studied. We examined the cytochrome P4501A (CYP1A)-catalyzed deethylation of 7-ethoxyresorufin (EROD) in the CAM during chicken embryo development. EROD was constitutively present and was inducible by the aryl hydrocarbon (Ah) receptor agonist 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126). Our results suggest the CAM as a first line of defence of the avian embryo against toxic compounds, but also as a target for CYP1A-activated chemicals.

Place, publisher, year, edition, pages
1999. Vol. 8, no 1, 49-52 p.
Keyword [en]
CAM, chorioallantoic membrane, CYP1A, EROD, PCB 126
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-77909DOI: 10.1016/S1382-6689(99)00030-7ISI: 000083994300006OAI: oai:DiVA.org:uu-77909DiVA: diva2:105822
Available from: 2005-05-26 Created: 2005-05-26 Last updated: 2017-12-14Bibliographically approved

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Brandt, IngvarBrittebo, Eva BBrunström, Björn

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