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Breakdown of Blood-Brain and Blood-Spinal Cord Barriers During Acute Methamphetamine Intoxication: Role of Brain Temperature
NIDA, Behav Neurosci Branch, Intramural Res Program, NIH, 333 Cassell Dr, Baltimore, MD 21224 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2016 (English)In: CNS & Neurological Disorders: Drug Targets, ISSN 1871-5273, E-ISSN 1996-3181, Vol. 15, no 9, 1129-1138 p.Article, review/survey (Refereed) Published
Abstract [en]

Methamphetamine (METH) is a powerful and often-abused stimulant with potent addictive and neurotoxic properties. While it is generally believed that structural brain damage induced by METH results from oxidative stress, in this work we present data suggesting robust disruption of blood-brain and blood-spinal cord barriers during acute METH intoxication in rats. We demonstrate the relationships between METH-induced brain hyperthermia and widespread but structure-specific barrier leakage, acute glial cell activation, changes in brain water and ionic homeostasis, and structural damage of different types of cells in the brain and spinal cord. Therefore, METH-induced leakage of the blood-brain and blood-spinal cord barriers is a significant contributor to different types of functional and structural brain abnormalities that determine acute toxicity of this drug and possibly neurotoxicity during its chronic use.

Place, publisher, year, edition, pages
2016. Vol. 15, no 9, 1129-1138 p.
Keyword [en]
Brain edema, brain hyperthermia, cellular damage, methamphetamine, neurotoxicity, psychomotor stimulants, skin vasoconstriction
National Category
Neurology Pharmacology and Toxicology
URN: urn:nbn:se:uu:diva-311091DOI: 10.2174/1871527315666160920112445ISI: 000387125600010PubMedID: 27658516OAI: oai:DiVA.org:uu-311091DiVA: diva2:1058554
NIH (National Institute of Health)
Available from: 2016-12-21 Created: 2016-12-21 Last updated: 2016-12-21Bibliographically approved

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Sharma, Hari S.
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Anaesthesiology and Intensive Care
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