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Screening of circulating microRNA biomarkers for prevalence of abdominal aortic aneurysm and aneurysm growth
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Vascular Surgery.
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2017 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 256, 82-88 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND AIMS: MicroRNA (miR) are important regulators of gene expression and biological processes and have recently been suggested as possible biomarkers for abdominal aortic aneurysm (AAA) disease. The aim of the present study was to assess the role of miR as biomarkers for initiation and progression of AAA disease, through evaluation of a wide range of miRs in a large population-based cohort, with AAA patients with linked clinical data regarding risk factors, AAA size and growth, as well as controls.

METHODS: The expression of the 172 most commonly expressed miRs in plasma was analyzed by real-time PCR in samples from 169 screening-detected AAA patients and 48 age-matched controls.

RESULTS: For 103 miRs, there was a significant difference in expression between AAA and controls. Of these, 20 miRs were differently expressed between fast and slow growing aneurysms. These miRs target genes known to be involved in AAA disease as well as novel genes and pathways. By combining the top altered miRs together with clinical variables, strong predictive values, determining growth of AAA, were obtained (area under curve = 0.86, p < 0.001).

CONCLUSIONS: This large cohort study identified several novel miRs with altered expression in AAA patients when compared to controls. Assessment of miR expression may offer an opportunity to predict disease progression and aneurysm growth.

Place, publisher, year, edition, pages
2017. Vol. 256, 82-88 p.
Keyword [en]
Biomarker, Plasma, Risk factor, Aneurysm, MicroRNA
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-311129DOI: 10.1016/j.atherosclerosis.2016.11.007ISI: 000393891900012PubMedID: 27993388OAI: oai:DiVA.org:uu-311129DiVA: diva2:1058740
Funder
Swedish Research Council, K2013-99X-22231-01-5; K2013-64X-20406-07-3Swedish Heart Lung Foundation, 2012-0353; 2015-0596; 2013-0650Åke Wiberg Foundation, M15-0009The King Gustaf V's Jubilee Foundation
Available from: 2016-12-21 Created: 2016-12-21 Last updated: 2017-04-18Bibliographically approved

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