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Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrution)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
2006 (English)In: NMCD. Nutrition Metabolism and Cardiovascular Diseases, ISSN 0939-4753, E-ISSN 1590-3729, Vol. 16, no 2, 128-136 p.Article in journal (Refereed) Published
Abstract [en]

It is known that the fatty acid (FA) composition in serum cholesteryl esters to a certain extent mirrors not only the FA composition of dietary fat, but also the endogenous FA synthesis, where desaturases play an important part. A surrogate measure of Δ9-, Δ6- and Δ5-desaturase activity can be calculated as a [product:precursor] fatty acid ratio. Δ9-Desaturase activity is known to be high in conditions like diabetes, atherosclerosis and obesity. The aim of the present study was to relate the proportions of individual fatty acids in serum cholesteryl esters, as well as estimated desaturase ratios to markers of obesity and lifestyle variables (smoking, physical activity and dietary fat). We also studied gender differences. These relationships were studied in a reference population consisting of men (n=554) and women (n=295) who took part in a health survey concerning coronary heart disease in Sweden. We found positive and significant correlations between markers of obesity and the proportions of 16:0, 16:1 (n-7), 18:0, 18:3 (n-6), 20:3 (n-6), 20:4 (n-6), 20:5 (n-3), Δ9 and Δ6 activities, and an inverse correlation to Δ5 activity and 18:2 (n-6). These relationships were independent of age and physical activity and in some cases of body mass index (BMI). For each standard deviation (SD) increase of Δ9 and Δ6 activities, the risk of being overweight was increased by about 60%, whereas the risk was reduced to about 30% for every SD increase of Δ5 activity. Women were found to have significantly higher levels of Δ9 and lower levels of Δ6 desaturase activities than men. In conclusion, this study shows that a changed FA profile in serum cholesteryl esters and estimated desaturase activities are associated with obesity and lifestyle factors in men and women.

Place, publisher, year, edition, pages
2006. Vol. 16, no 2, 128-136 p.
Keyword [en]
Fatty acid composition, Desaturase, Stearoyl-CoA desaturase, Obesity
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-77983DOI: 10.1016/j.numecd.2005.06.001PubMedID: 16487913OAI: oai:DiVA.org:uu-77983DiVA: diva2:105896
Available from: 2006-03-16 Created: 2006-03-16 Last updated: 2010-05-27Bibliographically approved

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Warensjö, EvaÖhrvall, MargaretaVessby, Bengt

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