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Intra-individual variations and time trends 1991-2001 in human serum levels of PCB, DDE and hexachlorobenzene
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences. (Clinical Nutrition)
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2006 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 64, no 9, 1507-1513 p.Article in journal (Refereed) Published
Abstract [en]

Background: An important question is whether human serum levels of persistent organic pollutants has continued to decrease during the last decades. The aim of this study was to assess intra-individual variations over time of serum levels of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153), 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethene (p,p'-DDE) and hexachlorobenzene (HCB), considering the impact of a number of possible determinants.

Methods: Blood samples were drawn for the same 39 subjects in 1991 and 2001. Interviews were made at both occasions. Lipid adjusted serum concentrations of CB-153, p,p'-DDE and HCB were determined in both sets of blood samples using gas chromatography-mass spectrometry. The fatty acid composition of the serum lipids was analyzed by means of gas-liquid chromatography.

Result: The CB-153 concentrations in serum had averagely decreased with 34% in between 1991 and 2001 (p < 0.001). Of individual determinants only increasing BMI was associated with decreasing CB-153 levels (beta = -1.0, 95% CI -1.8, -0.2, p = 0.01), explaining 13% of the variation. The average decrease of p,p'-DDE was 55%, and could only weakly be associated with a relative increase of BMI (beta = - 1.0, 95% CI-2.3, 0.2, p=0.09), explaining only 5% of the variation. The average decrease of HCB was 53%, and was associated only with high fish consumption in 1991, explaining 12% of the variation.

Conclusions: The results support a continuing decrease in human body burdens of PCBs, DDE and HCB during the 1990s. The explanatory factors relative change of BMI and fish consumption explained only a minor part of the time-related variations in serum levels.

Place, publisher, year, edition, pages
2006. Vol. 64, no 9, 1507-1513 p.
Keyword [en]
body mass index, dietary contamination, exposure determinants, follow up study
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-78003DOI: 10.1016/j.chemosphere.2005.12.054ISI: 000240650200010PubMedID: 16466768OAI: oai:DiVA.org:uu-78003DiVA: diva2:105916
Available from: 2008-04-16 Created: 2008-04-16 Last updated: 2011-06-16Bibliographically approved

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