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FRISC score for selection of patients for an early invasive treatment strategy in unstable coronary artery disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2005 (English)In: Heart, ISSN 1355-6037, E-ISSN 1468-201X, Vol. 91, no 8, 1047-1052 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To develop a scoring system for risk stratification and evaluation of the effect of an early invasive strategy for treatment of unstable coronary artery disease (CAD).

Design: Retrospective analysis of a randomised study (FRISC II; fast revascularisation in instability in coronary disease).

Setting: 58 Scandinavian hospitals.

Patients: 2457 patients with unstable CAD from the FRISC II study.

Main outcome measures: One year rates of mortality and death/myocardial infarction (MI).

Methods: Patients were randomly assigned to an early invasive or a non-invasive strategy. From the non-invasive cohort independent variables of death or death/MI were identified.

Results: Seven factors, age > 70 years, male sex, diabetes, previous MI, ST depression, and increased concentrations of troponins and markers of inflammation (interleukin 6 or C reactive protein), were associated with an independent increased risk for death or death/MI. In patients with ≥ 5 of these factors the invasive strategy reduced mortality from 15.4% (20 of 130) to 5.2% (7 of 134) (risk ratio (RR) 0.34, 95% confidence interval (CI) 0.15 to 0.78, p  =  0.006). Death/MI was also reduced in patients with 3–4 factors from 15.7% (80 of 511) to 10.8% (58 of 538) (RR 0.69, 95% CI 0.50 to 0.94, p  =  0.02). Neither death nor death/MI was reduced in patients with 0–2 risk factors.

Conclusion: In unstable CAD, this scoring system based on factors independently associated with an adverse outcome can be used shortly after admission to the hospital for risk stratification and for selection of patients to an early invasive treatment strategy.

Place, publisher, year, edition, pages
2005. Vol. 91, no 8, 1047-1052 p.
Keyword [en]
Aged, Angina; Unstable/*surgery, Biological Markers/blood, Coronary Angiography/methods, Electrocardiography, Female, Follow-Up Studies, Humans, Male, Myocardial Infarction/*surgery, Myocardial Revascularization/*methods, Patient Selection, Retrospective Studies, Risk Factors, Survival Analysis, Treatment Outcome
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-78216DOI: 10.1136/hrt.2003.031369PubMedID: 16020594OAI: oai:DiVA.org:uu-78216DiVA: diva2:106129
Available from: 2007-03-07 Created: 2007-03-07 Last updated: 2010-05-26Bibliographically approved

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Lagerqvist, BLindahl, BStåhle, EVenge, PSiegbahn, AWallentin, L
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