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Surgical Replacement of Implantable Pulse Generator in Deep Brain Stimulation: Adverse Events and Risk Factors in a Multicenter Cohort
Karolinska Inst, Dept Clin Neurosci, Neurosurg, Stockholm, Sweden.;Umeå Univ, Dept Pharmacol & Clin Neurosci, Unit Funct & Stereotact Neurosurg, Umeå, Sweden.;Univ Queensland, Queensland Brain Inst, Asia Pacific Ctr Neuromodulat, Brisbane, Qld 4072, Australia..
Univ Queensland, Queensland Brain Inst, Asia Pacific Ctr Neuromodulat, Brisbane, Qld 4072, Australia..
Umeå Univ, Dept Pharmacol & Clin Neurosci, Unit Funct & Stereotact Neurosurg, Umeå, Sweden.;Sahlgrens Univ Hosp, Dept Neurosurg, Gothenburg, Sweden..
Linköping Univ Hosp, Dept Neurosurg, Linköping, Sweden..
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2016 (English)In: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 94, no 4, 235-239 p.Article in journal (Refereed) Published
Abstract [en]

Background: Deep brain stimulation (DBS) is a growing treatment modality, and most DBS systems require replacement of the implantable pulse generator (IPG) every few years. The literature regarding the potential impact of adverse events of IPG replacement on the longevity of DBS treatments is rather scarce. Objective: To investigate the incidence of adverse events, including postoperative infections, associated with IPG replacements in a multicenter cohort. Methods: The medical records of 808 patients from one Australian and five Swedish DBS centers with a total of 1,293 IPG replacements were audited. A logistic regression model was used to ascertain the influence of possible predictors on the incidence of adverse events. Results: The overall incidence of major infections was 2.3% per procedure, 3.7% per patient and 1.7% per replaced IPG. For 28 of 30 patients this resulted in partial or complete DBS system removal. There was an increased risk of infection for males (OR 3.6, p = 0.026), and the risk of infection increased with the number of prior IPG replacements (OR 1.6, p < 0.005). Conclusions: The risk of postoperative infection with DBS IPG replacement increases with the number of previous procedures. There is a need to reduce the frequency of IPG replacements.

Place, publisher, year, edition, pages
2016. Vol. 94, no 4, 235-239 p.
Keyword [en]
Deep brain stimulation, Implantable pulse generator, Hardware, Adverse event, Complication, Postoperative infection, Surgical site infection
National Category
Neurosciences Neurology
Identifiers
URN: urn:nbn:se:uu:diva-310569DOI: 10.1159/000447521ISI: 000387199800005PubMedID: 27554079OAI: oai:DiVA.org:uu-310569DiVA: diva2:1061373
Available from: 2017-01-02 Created: 2016-12-16 Last updated: 2017-01-02Bibliographically approved

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