Alcohol and Endogenous Opioids
2016 (English)In: Neuropathology of Drug Addictions and Substance Misuse: Volume 1: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids / [ed] Victor R. Preedy, Amsterdam: Academic Press, 2016, Vol. 1, 401-410 p.Chapter in book (Refereed)
The endogenous opioid system is involved in alcohol-induced reward and development of alcohol use disorder (AUD). Alcohol exposure induces a number of changes in the endogenous opioid system, both after acute and chronic intake. Opioid agonists and antagonists can modulate alcohol consumption and opioid antagonists are therefore used in pharmacotherapy of AUD. There are three different receptor types-mu-, delta- and kappa-opioid receptors-with different affinity for the three opioid peptides: beta-endorphin, enkephalin, and dynorphin. The three systems also mediate different effects. Positive effects are generally attributed to the endorphins and enkephalins, while negative effects are mediated by dynorphins. Dysfunction in any or all of these systems contribute to development of AUD. Genetic and environmental factors interact to cause long-term changes in endogenous opioid function, which can affect vulnerability to AUD and efficacy of treatment with opioid antagonists.
Place, publisher, year, edition, pages
Amsterdam: Academic Press, 2016. Vol. 1, 401-410 p.
Alcohol, Alcohol use disorder, Beta-endorphin, Dynorphin, Enkephalin, Individual response, Individual vulnerability, Nalmefene, Naltrexone, Neuropeptides
IdentifiersURN: urn:nbn:se:uu:diva-310247DOI: 10.1016/B978-0-12-800213-1.00037-7ScopusID: 2-s2.0-84969663906ISBN: 9780128003763ISBN: 9780128002131OAI: oai:DiVA.org:uu-310247DiVA: diva2:1061703