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TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells
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2017 (English)In: Cell reports, ISSN 2211-1247, E-ISSN 2211-1247, Vol. 18, no 1, 1-11 p.Article in journal (Refereed) Published
Abstract [en]

Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.

Place, publisher, year, edition, pages
Elsevier , 2017. Vol. 18, no 1, 1-11 p.
National Category
Neurosciences Genetics Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-311976DOI: 10.1016/j.celrep.2016.12.010ISI: 000396465300001PubMedID: 28052240OAI: oai:DiVA.org:uu-311976DiVA: diva2:1061971
Funder
Swedish Research Council, K2014-62X-22527-01-3 2015-02429Swedish Foundation for Strategic Research , FFL12-0074The Swedish Brain Foundation, FO2015-0040Swedish Cancer Society, 150279
Available from: 2017-01-04 Created: 2017-01-04 Last updated: 2017-04-07Bibliographically approved

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