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Exploiting Bisphosphonate-Bioactive-Glass Interactions for the Development of Self-Healing and Bioactive Composite Hydrogels
Radboud Univ Nijmegen Med Ctr, Dept Biomat, NL-6525 EX Nijmegen, Netherlands..
Radboud Univ Nijmegen Med Ctr, Dept Biomat, NL-6525 EX Nijmegen, Netherlands..
Heinrich Heine Univ Dusseldorf, Inst Organ & Macromol Chem, D-40225 Dusseldorf, Germany..
Univ Utrecht, Fac Sci, UIPS, Dept Pharmaceut, NL-3508 TB Utrecht, Netherlands..
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2016 (English)In: Macromolecular rapid communications, ISSN 1022-1336, E-ISSN 1521-3927, Vol. 37, no 23, 1952-1959 p.Article in journal (Refereed) Published
Abstract [en]

Hydrogels are widely recognized as promising candidates for various biomedical applications, such as tissue engineering. Recently, extensive research efforts have been devoted to the improvement of the biological and mechanical performance of hydrogel systems by incorporation of functional groups and/or inorganic particles in their composition. Bisphosphonates are a class of drugs, commonly used for treatment of osteoporosis, which exhibit a strong binding affinity for hydroxyapatite. In this study, the binding affinity of a bisphosphonate-functionalized polymer, hyaluronan, toward a bioactive glass (i.e., 45S5 Bioglass) is evaluated using force-distance measurements with atomic force microscopy. The strong interaction between bisphosphonate and bioactive glass is then exploited to develop organic-inorganic composite hydrogels and the viscoelastic and self-healing ability of these materials are investigated. Finally, the stability and mineralization behavior of these hydrogels are evaluated in simulated body fluid. Following this approach, injectable, bioactive and self-healing organic-inorganic composite hydrogels are produced, which mineralize abundantly and rapidly in simulated body fluid. These properties render these composite gels suitable for applications in bone-tissue engineering.

Place, publisher, year, edition, pages
2016. Vol. 37, no 23, 1952-1959 p.
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-312059DOI: 10.1002/marc.201600353ISI: 000389125300012OAI: oai:DiVA.org:uu-312059DiVA: diva2:1062181
Available from: 2017-01-04 Created: 2017-01-04 Last updated: 2017-01-04Bibliographically approved

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