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The prognostic impact of SYT-SSX fusion type and histological grade in pediatric patients with synovial sarcoma treated according to the CWS (Cooperative Weichteilsarkom Studie) trials
Klinikum Stuttgart, Olgahosp, Pediat Oncol Hematol Immunol 5, Kriegsbergstr 62, D-70174 Stuttgart, Germany..
Univ Kiel, Dept Paediat Pathol, Kiel Paediat Tumor Registry, Kiel, Germany..
Inst Pathol Munich Nord, Munich, Germany..
St Anna Childrens Hosp, Vienna, Austria..
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2017 (English)In: Pediatric Blood & Cancer, ISSN 1545-5009, E-ISSN 1545-5017, Vol. 64, no 1, 89-95 p.Article in journal (Refereed) Published
Abstract [en]

BackgroundThe aim of our analysis was the evaluation of the prognostic impact of SYT-SSX fusion status and histological grading in synovial sarcoma (SS) of children and adolescents in the context of the consistent multimodal treatment strategy of the CWS (Cooperative Weichteilsarkom Studie; Cooperative Soft Tissue Sarcoma Study Group) and in comparison with other risk factors. ProcedureBetween 1986 and 2006, out of 243 patients with SS, tumor samples from 84 patients with localized disease were available for RT-PCR analysis. Outcome depending on fusion status in the context with known clinical risk factors was analyzed. ResultsNo prognostic significance was shown for SYT-SSX fusion status and for histological grade. Highest significance of negative prognostic impact was found for large tumor size in uni- and multivariate analysis (P < 0.01). Furthermore, male gender was shown to be an adverse prognostic factor in multivariate analysis (P = 0.01). ConclusionsBased on our results, neither histological grading nor SYT-SSX fusion status seems to be suitable for outcome prediction and risk stratification in localized SS treated according to the CWS. This is in contrast to several other publications concerning more heterogeneous age groups including children and adults, and this indicates that prognostic factors should not be interpreted apart from the particular study population and the therapeutic context.

Place, publisher, year, edition, pages
2017. Vol. 64, no 1, 89-95 p.
Keyword [en]
CWS, grading, prognosis, soft-tissue sarcoma, synovial sarcoma, SYT-SSX
National Category
Cancer and Oncology Hematology Pediatrics
Identifiers
URN: urn:nbn:se:uu:diva-312032DOI: 10.1002/pbc.26206ISI: 000389051100013PubMedID: 27621063OAI: oai:DiVA.org:uu-312032DiVA: diva2:1062393
Available from: 2017-01-05 Created: 2017-01-04 Last updated: 2017-01-05Bibliographically approved

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