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Protein-tyrosine phosphatases and cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm , Ludwig Institute for Cancer Research.
2006 (English)In: Nature Reviews. Cancer, ISSN 1474-175X, Vol. 6, no 4, 307-320 p.Article, review/survey (Refereed) Published
Abstract [en]

Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer drugs have been introduced that target these enzymes. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). Recent evidence has shown that PTPs can function as tumour suppressors. In addition, some PTPs, including SHP2, positively regulate the signalling of growth-factor receptors, and can be oncogenic. An improved understanding of how these enzymes function and how they are regulated might aid the development of new anticancer agents.

Place, publisher, year, edition, pages
2006. Vol. 6, no 4, 307-320 p.
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Medical and Health Sciences
URN: urn:nbn:se:uu:diva-78719DOI: 10.1038/nrc1837PubMedID: 16557282OAI: oai:DiVA.org:uu-78719DiVA: diva2:106632
Available from: 2006-03-29 Created: 2006-03-29 Last updated: 2011-03-01Bibliographically approved

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