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Alteration in the brain content of substance P (1-7) during withdrawal in morphine-dependent rats
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
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1998 (English)In: NEUROPHARMACOLOGY, ISSN 0028-3908, Vol. 37, no 12, 1545-1552 p.Article in journal (Other scientific) Published
Abstract [en]

Previous studies have shown that substance P (SP) may modulate the abstinence reaction to opioid withdrawal. Its N-terminal fragment SP1-7 may inhibit the intensity of the withdrawal reactions in morphine dependent mice, This study was designed to determi

Place, publisher, year, edition, pages
1998. Vol. 37, no 12, 1545-1552 p.
Keyword [en]
morphine; dependence; withdrawal; substance P; substance P N-terminal fragment; rat brain; HUMAN CEREBROSPINAL-FLUID; CONVERTING ENZYME-ACTIVITIES; VENTRAL TEGMENTAL AREA; CENTRAL-NERVOUS-SYSTEM; GENE-RELATED PEPTIDE; MOUSE SPINAL-CORD; NUCLEUS-ACCUMBENS;
Identifiers
URN: urn:nbn:se:uu:diva-79031OAI: oai:DiVA.org:uu-79031DiVA: diva2:106944
Note
Addresses: Nyberg F, Uppsala Univ, Dept Pharmaceut Biosci, Div Biol Res Drug Dependence, POB 591, S-75124 Uppsala, Sweden. Uppsala Univ, Dept Pharmaceut Biosci, Div Biol Res Drug Dependence, S-75124 Uppsala, Sweden.Available from: 2005-05-26 Created: 2005-05-26 Last updated: 2011-01-14

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