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Enhanced interleukin-18 levels in the peripheral blood of children with coeliac disease
Department of Gastrointestinal Research, Pharmacia Diagnostics, Uppsala, Sweden. (Allmänpediatrisk forskning/Nordvall)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Women's and Children's Health, Pediatrics. (Allmänpediatrisk forskning/Nordvall)
Department of Gastrointestinal Research, Pharmacia Diagnostics, Uppsala, Sweden.
Department of Paediatrics, University Hospital of Turku, Turku, Finland.
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2005 (English)In: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 139, no 1, 138-143 p.Article in journal (Refereed) Published
Abstract [en]

Coeliac disease (CoD) is a small intestinal disorder characterized by villous atrophy, crypt cell hyperplasia and an increased production of T helper cell type 1 (Th1) cytokines. Interleukin (IL)-18 is a pro-inflammatory cytokine that has a crucial role in maintaining the Th1 response. In this study, the serum levels of IL-18 were measured in children with CoD or other gastrointestinal diseases in order to evaluate the possibility of using IL-18 as a disease activity marker. IL-18 levels were higher in samples from CoD patients [median 443 pg/ml (148-885)] compared to healthy controls [median 205 pg/ml (11-379)], P <0.05. In contrast, the levels of IL-18 were not enhanced significantly in the serum from patients with inflammatory bowel disease (IBD) [median 324 pg/ml (207-546)] or in the disease control group [median 303 pg/ml (2-689)]. In CoD patients, after 2 weeks of gluten challenge (GC), serum IL-18 was unchanged [median 268 pg/ml (59-458)] compared to patients on a gluten-free diet [median 220 pg/ml (53-600)], while IL-18 was increased after 12 weeks of GC [median 551 pg/ml (94-952)], P <0.01. The IL-18 levels correlated with IgA anti-transglutaminase antibody levels (rs=0.59, P=0.016) in serum from untreated CoD patients, and IL-18 also followed the degree of small intestinal villous atrophy in 12 out of 19 CoD patients. Our results support the view that serum IL-18 concentrations in children with CoD follow disease activity, suggesting a role for IL-18 in the induction of an inflammatory Th1-response after gluten exposure.

Place, publisher, year, edition, pages
2005. Vol. 139, no 1, 138-143 p.
Keyword [en]
Adolescent, Atrophy, Biological Markers/blood, Celiac Disease/*blood/immunology/pathology, Child, Child; Preschool, Diet; Protein-Restricted, Female, Gluten/immunology, Humans, Immunoglobulin A/blood, Infant, Inflammatory Bowel Diseases/blood/immunology, Interleukin-18/*blood, Intestine; Small/pathology, Male, Retrospective Studies, Transglutaminases/immunology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-79047DOI: 10.1111/j.1365-2249.2005.02661.xPubMedID: 15606624OAI: oai:DiVA.org:uu-79047DiVA: diva2:106960
Available from: 2006-04-03 Created: 2006-04-03 Last updated: 2017-12-14Bibliographically approved

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Lettesjö, HeleneHansson, TonyDannaeus, Anders

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