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Initiation factors IF1 and IF2 synergistically remove peptidyl-tRNAs with short polypeptides from the P-site of translating Escherichia coli ribosomes
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology.
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1998 (English)In: JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, Vol. 281, no 2, 241-252 p.Article in journal (Other scientific) Published
Abstract [en]

A novel function of initiation factors IF1 and IF2 in Escherichia coli translation has been identified. It is shown that these factors efficiently catalyse dissociation of peptidyl-tRNAs with polypeptides of different length from the P-site of E. coli rib

Place, publisher, year, edition, pages
ACADEMIC PRESS LTD , 1998. Vol. 281, no 2, 241-252 p.
Keyword [en]
initiation factors; peptidyl-tRNAs; drop-off; ribosomal P-site; translation; TRANSFER-RNA HYDROLASE; PROTEIN-SYNTHESIS; GENE-EXPRESSION; A-SITE; DISSOCIATION; SUPPRESSION; PURIFICATION; BINDING; ERRORS
Identifiers
URN: urn:nbn:se:uu:diva-79174OAI: oai:DiVA.org:uu-79174DiVA: diva2:107087
Note
Addresses: Ehrenberg M, Biomed Ctr, Dept Biol Mol, Box 590, S-75124 Uppsala, Sweden. Biomed Ctr, Dept Biol Mol, S-75124 Uppsala, Sweden. Inst Biol Physicochim, CNRS, UPR 9073, F-75005 Paris, France.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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