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Mutations in RNAs of both ribosomal subunits cause defects in translation termination
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology.
1998 (English)In: EMBO JOURNAL, ISSN 0261-4189, Vol. 17, no 5, 1507-1514 p.Article in journal (Other scientific) Published
Abstract [en]

Mutations in RNAs of both subunits of the Escherichia coil ribosome caused defects in catalysis of peptidyl-tRNA hydrolysis in a realistic in vitro termination system. Assaying the two codon-dependent cytoplasmic proteins that drive termination, RF1 and R

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 1998. Vol. 17, no 5, 1507-1514 p.
Keyword [en]
in vitro termination; mutant rRNAs; protein synthesis; RF2 defect; ESCHERICHIA-COLI; STOP SIGNAL; PEPTIDYL TRANSFERASE; CHAIN TERMINATION; PROTEIN-SYNTHESIS; THIOSTREPTON; EXPRESSION; SUPPRESSOR; RESISTANCE; BINDING
Identifiers
URN: urn:nbn:se:uu:diva-79317OAI: oai:DiVA.org:uu-79317DiVA: diva2:107230
Note
Addresses: Murgola EJ, Univ Texas, MD Anderson Cancer Ctr, Dept Mol Genet, Box 11, 1515 Holcombe Blvd, Houston, TX 77030 USA. Univ Texas, MD Anderson Cancer Ctr, Dept Mol Genet, Houston, TX 77030 USA. Uppsala Univ, Dept Mol Biol, Ctr Biomed, S-75124 UppsaAvailable from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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