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Morphine alters the levels of growth hormone receptor-mRNA and [I-125]growth hormone binding in human IM-9 lymphoblasts via a naloxone-reversible mechanism
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
1997 (English)In: MOLECULAR AND CELLULAR ENDOCRINOLOGY, ISSN 0303-7207, Vol. 135, no 2, 147-152 p.Article in journal (Other scientific) Published
Abstract [en]

The immune system and the neuroendocrine system are functionally interactive. Lymphocytes possess opioid receptors as well as growth hormone receptors (GHR) by which opioids and growth hormone (GH) may modulate immune functions. In this study, we have inv

Place, publisher, year, edition, pages
1997. Vol. 135, no 2, 147-152 p.
Keyword [en]
growth hormone receptor; morphine; Northern blot; receptor binding; IM-9 lymphoblasts; HUMAN CULTURED LYMPHOCYTES; IMMUNE-SYSTEM; CELL-LINES; RADIORECEPTOR ASSAY; BLOOD LYMPHOCYTES; GENE-EXPRESSION; MESSENGER-RNA; GH; PROLIFERATION; LEUKOCYTES
Identifiers
URN: urn:nbn:se:uu:diva-79389OAI: oai:DiVA.org:uu-79389DiVA: diva2:107302
Note
Addresses: Le Greves P, Uppsala Univ, BMC, Dept Pharmaceut Biosci, Div Biol Res Drug Dependence, Box 591, S-75124 Uppsala, Sweden. Uppsala Univ, BMC, Dept Pharmaceut Biosci, Div Biol Res Drug Dependence, S-75124 Uppsala, Sweden.Available from: 2005-05-26 Created: 2005-05-26 Last updated: 2011-01-15

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