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Natural history of gastro-oesophageal reflux disease diagnosed in general practice
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
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2004 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, ISSN 0269-2813, Vol. 20, no 7, 751-760 p.Article in journal (Refereed) Published
Abstract [en]

Background : Cross-sectional studies indicate that gastro-oesophageal reflux disease symptoms have a prevalence of 10–20% in Western countries and are associated with obesity, smoking, oesophagitis, chest pain and respiratory disease.

Aim : To determine the natural history of gastro-oesophageal reflux disease presenting in primary care in the UK.

Methods : Patients with a first diagnosis of gastro-oesophageal reflux disease during 1996 were identified in the UK General Practice Research Database and compared with age- and sex-matched controls. We investigated the incidence of gastro-oesophageal reflux disease, potential risk factors and comorbidities, and relative risk for subsequent oesophageal complications and mortality.

Results : The incidence of a gastro-oesophageal reflux disease diagnosis was 4.5 per 1000 person-years (95% confidence interval: 4.4–4.7). Prior use of non-steroidal anti-inflammatory drugs, smoking, excess body weight and gastrointestinal and cardiac conditions were associated with an increased risk of gastro-oesophageal reflux disease diagnosis. Subjects with gastro-oesophageal reflux disease had an increased risk of respiratory problems, chest pain and angina in the year after diagnosis, and had a relative risk of 11.5 (95% confidence interval: 5.9–22.3) of being diagnosed with an oesophageal complication. There was an increase in mortality in the gastro-oesophageal reflux disease cohort only in the year following the diagnosis.

Conclusions : Gastro-oesophageal reflux disease is a disease associated with a range of potentially serious oesophageal complications and extra-oesophageal diseases.

Place, publisher, year, edition, pages
2004. Vol. 20, no 7, 751-760 p.
Keyword [en]
Adolescent, Adult, Aged, Anti-Inflammatory Agents; Non-Steroidal/adverse effects, Antirheumatic Agents/adverse effects, Child, Child; Preschool, Cohort Studies, Family Practice/statistics & numerical data, Female, Gastroesophageal Reflux/*etiology/mortality, Great Britain/epidemiology, Humans, Infant, Male, Middle Aged, Nitrates/adverse effects, Patient Acceptance of Health Care/statistics & numerical data, Research Support; Non-U.S. Gov't, Risk Factors, Steroids/adverse effects
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Medical and Health Sciences
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URN: urn:nbn:se:uu:diva-79650DOI: 10.1111/j.1365-2036.2004.02169.xPubMedID: 15379835OAI: oai:DiVA.org:uu-79650DiVA: diva2:107563
Available from: 2006-04-11 Created: 2006-04-11 Last updated: 2017-12-14Bibliographically approved

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Wallander, Mari-Ann

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