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Association between captopril, other antihypertensive drugs and risk of prostate cancer
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Clinical Chemistry.
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2004 (English)In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 58, no 1, 50-56 p.Article in journal (Refereed) Published
Abstract [en]


There has been some debate on the existence of an association between hypertension, antihypertensive medications and cancer risk.


We performed a nested case-control study to assess the association between the risk of prostate cancer and the use of the angiotensin converting enzyme (ACE)-inhibitor captopril, and other antihypertensive drugs. We used data from the General Practice Research Database in UK.


We found an incidence rate of prostate cancer of 1.61 per 1,000 person-years among male patients aged 50–79 years old. Patients with a history of benign prostatic hyperplasia and/or prostatism carried a two-fold greater risk of prostate cancer than those without such antecedents. None of the other studied co-morbidities were associated with prostate cancer. We found that users of captopril had a relative risk of 0.7 (95% CI: 0.4–1.2) to develope prostate cancer. None of the other studied individual ACE-inhibitors shared a similar effect with the one observed for captopril.


No clear association was apparent between the use of antihypertensive drugs and prostate cancer. However, specific focus on users of captopril showed a lower risk of subsequent prostate cancer. Further research is needed to explore this association.

Place, publisher, year, edition, pages
2004. Vol. 58, no 1, 50-56 p.
Keyword [en]
prostate, prostasomes, prostate cancer, angiotensin-I-converting enzyme, captopril, metalloproteases
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-79652DOI: 10.1002/pros.10294PubMedID: 14673952OAI: oai:DiVA.org:uu-79652DiVA: diva2:107565
Available from: 2007-03-21 Created: 2007-03-21 Last updated: 2011-09-26Bibliographically approved

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Ronquist, GunnarWallander, Mari-AnnSvärdsudd, K
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