Microalbuminuria and risk factors in type 1 and type 2 diabetic patients
2005 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 67, no 3, 258-66 p.Article in journal (Refereed) Published
A prospective study of normoalbuminuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20–200μg/min) were elevated HbA1c and diabetes duration in both types 1 and 2 diabetic patients. Other risk factors were high BMI, elevated systolic and diastolic BP in type 2 patients, and antihypertensive therapy in type 1 patients.
A subsequent larger cross-sectional study in 2002 showed that established microalbuminuria was independently associated with HbA1c, diabetes duration, systolic BP, BMI, smoking and triglycerides in types 1 and 2 diabetic patients, and also with HDL-cholesterol in type 2 patients. Relatively few types 1 and 2 patients with microalbuminuria achieved treatment targets of HbA1c < 6.5% (21–48%), BP < 130/85mmHg (33–13%), cholesterol < 5mmol/l (48–46%), triglycerides < 1.7mmol/l (83–48%) and BMI < 25kg/m2 (50–18%), respectively.
In conclusion, high HbA1c, BP and BMI were independent risk factors for the development of microalbuminuria in types 1 and 2 diabetic patients. These risk factors as well as triglycerides, HDL-cholesterol and smoking were independently associated with established microalbuminuria. Treatment targets were achieved by a relatively few patients with microalbuminuria.
Place, publisher, year, edition, pages
2005. Vol. 67, no 3, 258-66 p.
Adult, Albuminuria/*complications, Blood Pressure, Body Mass Index, Cross-Sectional Studies, Diabetes Mellitus; Type 1/epidemiology/*urine, Diabetes Mellitus; Type 2/epidemiology/*urine, Diabetic Nephropathies/*epidemiology, Female, Hemoglobin A; Glycosylated/analysis, Humans, Hypertension/epidemiology, Male, Middle Aged, Registries, Regression Analysis, Research Support; Non-U.S. Gov't, Risk Factors, Smoking/epidemiology, Sweden/epidemiology
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-79663DOI: 10.1016/j.diabres.2004.07.021PubMedID: 15713359OAI: oai:DiVA.org:uu-79663DiVA: diva2:107576