uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Microalbuminuria and risk factors in type 1 and type 2 diabetic patients
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
Show others and affiliations
2005 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 67, no 3, 258-66 p.Article in journal (Refereed) Published
Abstract [en]

A prospective study of normoalbuminuric diabetic patients was performed between 1997 and 2002 on 4097 type 1 and 6513 type 2 diabetic patients from the Swedish National Diabetes Register (NDR); mean study period, 4.6 years. The strongest independent baseline risk factors for the development of microalbuminuria (20–200μg/min) were elevated HbA1c and diabetes duration in both types 1 and 2 diabetic patients. Other risk factors were high BMI, elevated systolic and diastolic BP in type 2 patients, and antihypertensive therapy in type 1 patients.

A subsequent larger cross-sectional study in 2002 showed that established microalbuminuria was independently associated with HbA1c, diabetes duration, systolic BP, BMI, smoking and triglycerides in types 1 and 2 diabetic patients, and also with HDL-cholesterol in type 2 patients. Relatively few types 1 and 2 patients with microalbuminuria achieved treatment targets of HbA1c < 6.5% (21–48%), BP < 130/85mmHg (33–13%), cholesterol < 5mmol/l (48–46%), triglycerides < 1.7mmol/l (83–48%) and BMI < 25kg/m2 (50–18%), respectively.

In conclusion, high HbA1c, BP and BMI were independent risk factors for the development of microalbuminuria in types 1 and 2 diabetic patients. These risk factors as well as triglycerides, HDL-cholesterol and smoking were independently associated with established microalbuminuria. Treatment targets were achieved by a relatively few patients with microalbuminuria.

Place, publisher, year, edition, pages
2005. Vol. 67, no 3, 258-66 p.
Keyword [en]
Adult, Albuminuria/*complications, Blood Pressure, Body Mass Index, Cross-Sectional Studies, Diabetes Mellitus; Type 1/epidemiology/*urine, Diabetes Mellitus; Type 2/epidemiology/*urine, Diabetic Nephropathies/*epidemiology, Female, Hemoglobin A; Glycosylated/analysis, Humans, Hypertension/epidemiology, Male, Middle Aged, Registries, Regression Analysis, Research Support; Non-U.S. Gov't, Risk Factors, Smoking/epidemiology, Sweden/epidemiology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-79663DOI: 10.1016/j.diabres.2004.07.021PubMedID: 15713359OAI: oai:DiVA.org:uu-79663DiVA: diva2:107576
Available from: 2007-03-21 Created: 2007-03-21 Last updated: 2012-01-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15713359&dopt=Citation

Search in DiVA

By author/editor
Cederholm, Jan
By organisation
Family Medicine and Clinical Epidemiology
In the same journal
Diabetes Research and Clinical Practice
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 146 hits
ReferencesLink to record
Permanent link

Direct link