Acute effects of a fungal volatile compound
2005 (English)In: Journal of Environmental Health Perspectives, ISSN 0091-6765, E-ISSN 1552-9924, Vol. 113, no 12, 1775-1778 p.Article in journal (Refereed) Published
OBJECTIVE: 3-Methylfuran (3-MF) is a common fungal volatile product with active biologic properties, and previous studies have indicated a contribution to airway disease. The aim of the present study was to assess the acute health effects of this compound in humans.
DESIGN: Acute effects were assessed via chamber exposure to (1 mg/m3) 3-MF.
PARTICIPANTS AND MEASUREMENTS: Twenty-nine volunteers provided symptom reports, ocular electromyograms, measurement of eye tear film break-up time,vital staining of the eye, nasal lavage, acoustic rhinometry, transfer tests, and dynamic spirometry.
RESULTS: No subjective ratings were significantly increased during exposure. Blinking frequency and the lavage biomarkers myeloperoxidase and lysozyme were significantly increased, and forced vital capacity was significantly decreased during exposure to 3-MF compared with air control. CONCLUSIONS AND RELEVANCE TO CLINICAL PRACTICE: Acute effects in the eyes, nose, and airways were detected and might be the result of the biologically active properties of 3-MF. Thus, 3-MF may contribute to building-related illness.
Place, publisher, year, edition, pages
2005. Vol. 113, no 12, 1775-1778 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-79672DOI: 10.1289/ehp.8193.PubMedID: 16330362OAI: oai:DiVA.org:uu-79672DiVA: diva2:107585