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Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Cell Biology.
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2005 (English)In: Diabetologia, ISSN 0012-186X, Vol. 48, no 10, 2039-50 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2005. Vol. 48, no 10, 2039-50 p.
Keyword [en]
Animals, Apoptosis/*drug effects, Blotting; Western, Cell Separation, Cells; Cultured, Cytokines/*pharmacology, Dose-Response Relationship; Drug, Enzyme Activation/drug effects, Enzyme Inhibitors/pharmacology, Humans, Insulin/secretion, Insulin-Secreting Cells/*drug effects/secretion, MAP Kinase Kinase 4/*genetics, Mice, Mitogen-Activated Protein Kinases/metabolism, NG-Nitroarginine Methyl Ester/pharmacology, Nitric Oxide/*physiology, Nitric Oxide Donors/pharmacology, Nitric Oxide Synthase Type II/antagonists & inhibitors, Oncogene Protein v-akt/*genetics, Research Support; Non-U.S. Gov't, S-Nitroso-N-Acetylpenicillamine/pharmacology, Signal Transduction, p38 Mitogen-Activated Protein Kinases/metabolism
URN: urn:nbn:se:uu:diva-79775PubMedID: 16132952OAI: oai:DiVA.org:uu-79775DiVA: diva2:107688
Available from: 2006-04-13 Created: 2006-04-13 Last updated: 2011-01-11

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