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Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Respiratory Medicine and Allergology.
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2017 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 23, no 8, 1345-1352 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To determine how the auto-antibodies (Abs) profilesoverlap in chronic hepatitis C infection (CHC) andautoimmune hepatitis (AIH) and correlate to liverdisease.METHODS: Levels of antinuclear Ab, smooth muscle antibody (SMA)and liver/kidney microsomal-1 (LKM-1) Ab and markersof liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20healthy controls using enzyme linked immunosorbentassay and other immune assays. RESULTS: We found that AIH patients had more severe liverdisease as determined by elevation of total IgG,alkaline phosphatase, total serum bilirubin and serumtransaminases and significantly higher prevalence ofthe three non-organ-specific autoantibodies (auto-Abs)than CHC patients. Antinuclear Ab, SMA and LKM-1 Abwere also present in 36% of CHC patients and relatedto disease severity. CHC cases positive for auto-Abswere directly comparable to AIH in respect of mostmarkers of liver damage and total IgG. These caseshad longer disease duration compared with auto-Abnegative cases, but there was no difference in gender,age or viral load. KLM-1+ Ab CHC cases showed bestoverlap with AIH. CONCLUSION: Auto-Ab levels in CHC may be important markers ofdisease severity and positive cases have a diseasesimilar to AIH. Auto-Abs might have a pathogenic roleas indicated by elevated markers of liver damage.Future studies will unravel any novel associationsbetween these two diseases, whether genetic or other.

Place, publisher, year, edition, pages
2017. Vol. 23, no 8, 1345-1352 p.
Keyword [en]
Autoantibody, Inflammatory diseases, Immune system, Hepatitis C virus, Smooth muscle antibody, Liver/kidney microsomal-1 autoantibody, Anti-nuclear antibody
National Category
Immunology in the medical area
Research subject
Infectious Diseases
Identifiers
URN: urn:nbn:se:uu:diva-316265DOI: 10.3748/wjg.v23.i8.1345ISI: 000395823500004PubMedID: 28293081OAI: oai:DiVA.org:uu-316265DiVA: diva2:1077525
Available from: 2017-02-28 Created: 2017-02-28 Last updated: 2017-04-28Bibliographically approved

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Publisher's full textPubMedhttp://www.wjgnet.com/1007-9327/full/v23/i8/1345.htm

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Amin, Kawa

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