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Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses and Granule Content
Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, BMC, Uppsala, Sweden..
Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, BMC, Uppsala, Sweden..
Univ Kentucky, Coll Med, Saha Cardiovasc Res Ctr, Wethington, KY USA..
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA..
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2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 2, e89311Article in journal (Refereed) Published
Abstract [en]

Nuclear receptor 4a3 (Nr4a3) is a transcription factor implicated in various settings such as vascular biology and inflammation. We have recently shown that mast cells dramatically upregulate Nuclear receptor 4a3 upon activation, and here we investigated the functional impact of Nuclear receptor 4a3 on mast cell responses. We show that Nuclear receptor 4a3 is involved in the regulation of cytokine/chemokine secretion in mast cells following activation via the high affinity IgE receptor. Moreover, Nuclear receptor 4a3 negatively affects the transcript and protein levels of mast cell tryptase as well as the mast cell's responsiveness allergen. Together, these findings identify Nuclear receptor 4a3 as a novel regulator of mast cell function.

Place, publisher, year, edition, pages
2014. Vol. 9, no 2, e89311
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-316864DOI: 10.1371/journal.pone.0089311ISI: 000331714700099PubMedID: 24586680OAI: oai:DiVA.org:uu-316864DiVA: diva2:1079165
Funder
Magnus Bergvall FoundationSwedish Cancer SocietySwedish Research Council Formas
Available from: 2017-03-07 Created: 2017-03-07 Last updated: 2017-03-07Bibliographically approved

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