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Using genotyping to predict responses to anti-hypertensive treatment
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Akut- och internmedicin)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences. (Clinical pharmacogenetics and Osteoporosis)
2005 (English)In: TIPS - Trends in Pharmacological Sciences, ISSN 0165-6147, E-ISSN 1873-3735, Vol. 26, no 9, 443-7 p.Article in journal (Refereed) Published
Abstract [en]

Hypertension is prevalent and affects approximately 1 in every 4 adults in the Western world. Although many drugs are effective in treating hypertension, an individual's response to treatment is unpredictable. Pharmacogenetics holds the promise of becoming a tool to predict this response but obstacles and shortcomings need to be overcome. Significant developments in molecular biology, including the sequencing of the genome, the cataloguing of genetic variation and the development of microarray techniques, enable analysis of many genotypes simultaneously. However, despite these technical advances there are, as yet, no clinical applications of pharmacogenetics in anti-hypertensive treatment. It is therefore necessary to design prospective pharmacogenetic studies that aim to identify a genetic profile that will predict the response to anti-hypertensive treatment.

Place, publisher, year, edition, pages
2005. Vol. 26, no 9, 443-7 p.
Keyword [en]
Antihypertensive Agents/*therapeutic use, Genotype, Humans, Hypertension/*drug therapy/genetics, Pharmacogenetics
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-80042DOI: 10.1016/j.tips.2005.07.008PubMedID: 16055200OAI: oai:DiVA.org:uu-80042DiVA: diva2:107956
Available from: 2006-05-03 Created: 2006-05-03 Last updated: 2010-05-06Bibliographically approved

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Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16055200&dopt=Citation

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Lind, LarsMelhus, Håkan

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