uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Synthetic approaches towards the multi target drug spironolactone and its potent analogues/derivatives
Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan..
Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan..
Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan..
Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan..
Show others and affiliations
2017 (English)In: Steroids, ISSN 0039-128X, E-ISSN 1878-5867, Vol. 118, 76-92 p.Article, review/survey (Refereed) Published
Abstract [en]

Spironolactone is a well-known multi-target drug and is specifically used for the treatment of high blood pressure and heart failure. It is also used for the treatment of edema, cirrhosis of the liver, malignant, pediatric, nephrosis and primary hyperaldosteronism. Spironolactone in association with thiazide diuretics treats hypertension and in association with furosemide treats bronchopulmonary dyspepsia. The therapeutic mechanism of action of spironolactone involves binding to intracellular mineralocorticoids receptors (MRs) in kidney epithelial cells, thereby inhibiting the binding of aldosterone. Since its first synthesis in 1957 there are several synthetic approaches have been reported throughout the years, Synthetic community has devoted efforts to improve the synthesis of spironolactone and to synthesize its analogues and derivatives. This review aims to provide comprehensive insight for the synthetic endeavors devoted towards the synthesis of a versatile drug spironolactone and its analogues/derivatives.

Place, publisher, year, edition, pages
2017. Vol. 118, 76-92 p.
Keyword [en]
Spironolactone, Canrenone, Eplerenone, Synthesis, Aldosterone
National Category
Endocrinology and Diabetes Medicinal Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-317099DOI: 10.1016/j.steroids.2016.12.010ISI: 000393001200011PubMedID: 28041953OAI: oai:DiVA.org:uu-317099DiVA: diva2:1080520
Available from: 2017-03-10 Created: 2017-03-10 Last updated: 2017-11-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

El-Seedi, Hesham

Search in DiVA

By author/editor
El-Seedi, Hesham
By organisation
Division of Pharmacognosy
In the same journal
Steroids
Endocrinology and DiabetesMedicinal Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 363 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf