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Seasonal variations of urate in a Swedish adult population
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centre for Research and Development, Gävleborg.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Biochemial structure and function.
2017 (English)In: Clinical Rheumatology, ISSN 0770-3198, E-ISSN 1434-9949Article in journal (Refereed) Epub ahead of print
Abstract [en]

Seasonality in the incidence and prevalence of gout has previously been reported but the cause of this seasonality in gout is not explained. The aim of this study was to evaluate possible seasonal variations of urate in a large unselected Swedish adult population. We analyzed 170,915 urate test results from patients at a tertiary care hospital between 2000 and 2016. The results were divided according to sex and sampling month of the year. The median urate values were overall higher in males compared to females and both males and females had peak urate concentrations in the summer months (June-August). There is a seasonal pattern for urate concentrations in a large Swedish population similar to the previously reported seasonality for gout. This may be clinically important and could contribute to the circannual variation of gout. The seasonal pattern should be recognized when evaluating patient results both in clinical practice and in research studies.

Place, publisher, year, edition, pages
2017.
Keyword [en]
Biological markers, Circannual variation, Gout, Humans, Urate, Uric acid
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:uu:diva-317226DOI: 10.1007/s10067-017-3591-zPubMedID: 28283767OAI: oai:DiVA.org:uu-317226DiVA: diva2:1080843
Available from: 2017-03-12 Created: 2017-03-12 Last updated: 2017-11-29Bibliographically approved

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Åkerblom, AxelWeitoft, TomasLarsson, Anders

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Åkerblom, AxelHelmersson-Karlqvist, JohannaWeitoft, TomasLarsson, Anders
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CardiologyUCR-Uppsala Clinical Research CenterBiochemial structure and functionCentre for Research and Development, Gävleborg
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Clinical Rheumatology
Rheumatology and Autoimmunity

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