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Polymorphism at the porcine Dominant white/KIT locus influence coat colour and peripheral blood cell measures
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
2005 (English)In: Animal Genetics, ISSN 0268-9146, E-ISSN 1365-2052, Vol. 36, no 4, 288-296 p.Article in journal (Refereed) Published
Abstract [en]

We have examined the phenotype of different KIT genotypes with regard to coat colour and several blood parameters (erythrocyte numbers and measures, total and differential leucocyte numbers, haematocrit and haemoglobin levels and serum components). The effect of two different iron supplement regimes (one or two iron injections) on the blood parameters was also examined. For a total of 184 cross-bred piglets (different combinations of Hampshire, Landrace and Yorkshire) blood parameters were measured four times during their first month of life, and the KIT genotypes of these and 70 additional cross-bred piglets were determined. Eight different KIT genotypes were identified, which confirms the large allelic diversity at the KIT locus in commercial pig populations. The results showed that pigs with different KIT genotypes differ both in coat colour and in haematological parameters. In general, homozygous Dominant white (I/I) piglets had larger erythrocytes with lower haemoglobin concentration, indicating a mild macrocytic anaemia. The effect of two compared with one iron injection was also most pronounced for the I/I piglets.

Place, publisher, year, edition, pages
2005. Vol. 36, no 4, 288-296 p.
Keyword [en]
Animals, Blood Cell Count, Comparative Study, Erythrocytes/*cytology/drug effects/metabolism, Genotype, Hair Color/*genetics, Hematocrit, Hemoglobins/metabolism, Iron/pharmacology, Polymorphism; Genetic, Quantitative Trait Loci/*genetics, Research Support; Non-U.S. Gov't, Sus scrofa/*genetics
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-80284DOI: 10.1111/j.1365-2052.2005.01320.xPubMedID: 16026338OAI: oai:DiVA.org:uu-80284DiVA: diva2:108198
Available from: 2006-05-05 Created: 2006-05-05 Last updated: 2017-12-14Bibliographically approved

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Pielberg, GerliAndersson, Leif

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