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Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
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2006 (English)In: Blood, ISSN 0006-4971, Vol. 107, no 2, 655-60 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2006. Vol. 107, no 2, 655-60 p.
Keyword [en]
Animals, Bone Marrow/metabolism, Cell Proliferation/drug effects, Comparative Study, Disease Models; Animal, Enzyme Activation, In Vitro, Insulin-Like Growth Factor I/pharmacology, Mice, Mice; Inbred C57BL, Microcirculation, Mitogen-Activated Protein Kinase 1/antagonists & inhibitors/metabolism, Multiple Myeloma/blood supply/*drug therapy/metabolism, Neovascularization; Pathologic/metabolism, Paraproteins/metabolism, Phosphorylation, Podophyllotoxin/*analogs & derivatives/pharmacology, Receptor; IGF Type 1/*antagonists & inhibitors/metabolism, Research Support; Non-U.S. Gov't, Survival Rate, Tumor Cells; Cultured, Vascular Endothelial Growth Factor A
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URN: urn:nbn:se:uu:diva-80292PubMedID: 16046527OAI: oai:DiVA.org:uu-80292DiVA: diva2:108206
Available from: 2008-05-21 Created: 2008-05-21 Last updated: 2011-01-11

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Jernberg-Wiklund, HelenaNilsson, Kenneth

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