uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis
Tel Aviv Univ, Sackler Fac Med, Dept Human Mol Genet & Biochem, IL-6997801 Tel Aviv, Israel..
Inst Pathol, Sheba Med Ctr, IL-5265601 Tel Hashomer, Israel..
Tel Aviv Univ, Sackler Fac Med, Dept Human Mol Genet & Biochem, IL-6997801 Tel Aviv, Israel.;Tel Aviv Univ, Sch Comp Sci, IL-6997801 Tel Aviv, Israel..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology. Uppsala University, Science for Life Laboratory, SciLifeLab.
Show others and affiliations
2016 (English)In: CELL SYSTEMS, ISSN 2405-4712, Vol. 2, no 3, 172-184 p.Article in journal (Refereed) Published
Abstract [en]

The genomic and transcriptomic landscapes of breast cancer have been extensively studied, but the proteomes of breast tumors are far less characterized. Here, we use high-resolution, high-accuracy mass spectrometry to perform a deep analysis of luminal-type breast cancer progression using clinical breast samples from primary tumors, matched lymph node metastases, and healthy breast epithelia. We used a super-SILAC mix to quantify over 10,000 proteins with high accuracy, enabling us to identify key proteins and pathways associated with tumorigenesis and metastatic spread. We found high expression levels of proteins associated with protein synthesis and degradation in cancer tissues, accompanied by metabolic alterations that may facilitate energy production in cancer cells within their natural environment. In addition, we found proteomic differences between breast cancer stages and minor differences between primary tumors and their matched lymph node metastases. These results highlight the potential of proteomic technology in the elucidation of clinically relevant cancer signatures.

Place, publisher, year, edition, pages
2016. Vol. 2, no 3, 172-184 p.
National Category
Cancer and Oncology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-317716DOI: 10.1016/j.cels.2016.02.001ISI: 000394358800007PubMedID: 27135363OAI: oai:DiVA.org:uu-317716DiVA: diva2:1082565
Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-03-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Lindskog, CeciliaPonten, Fredrik
By organisation
Clinical and experimental pathologyScience for Life Laboratory, SciLifeLabExperimental and Clinical Oncology
Cancer and OncologyCell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 15 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf