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Benchmark investigation of diamondoid-functionalized electrodes for nanopore DNA sequencing
Univ Stuttgart, Inst Computat Phys, Stuttgart, Germany..
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory. Univ Fed Fluminense, Dept Fis, ICEx, Volta Redonda, RJ, Brazil..ORCID iD: 0000-0001-9611-8772
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
Univ Stuttgart, Inst Computat Phys, Stuttgart, Germany..
2016 (English)In: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 27, no 41, 414002Article in journal (Refereed) Published
Abstract [en]

Small diamond-like particles, diamondoids, have been shown to effectively functionalize gold electrodes in order to sense DNA units passing between the nanopore-embedded electrodes. In this work, we present a comparative study of Au(111) electrodes functionalized with different derivatives of lower diamondoids. Focus is put on the electronic and transport properties of such electrodes for different DNA nucleotides placed within the electrode gap. The functionalization promotes a specific binding to DNA leading to different properties for the system, which provides a tool set to systematically improve the signal-to-noise ratio of the electronic measurements across the electrodes. Using quantum transport calculations, we compare the effectiveness of the different functionalized electrodes in distinguishing the four DNA nucleotides. Our results point to the most effective diamondoid functionalization of gold electrodes in view of biosensing applications.

Place, publisher, year, edition, pages
2016. Vol. 27, no 41, 414002
Keyword [en]
DNA sequencing, quantum transport, density functional theory, diamondoids, nanopore, nanogap
National Category
Condensed Matter Physics
Identifiers
URN: urn:nbn:se:uu:diva-317710DOI: 10.1088/0957-4484/27/41/414002ISI: 000394367200001PubMedID: 27607107OAI: oai:DiVA.org:uu-317710DiVA: diva2:1082591
Funder
German Research Foundation (DFG), SFB 716Carl Tryggers foundation Swedish Research Council
Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-11-29Bibliographically approved

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Amorim, Rodrigo G.Scheicher, Ralph H.

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