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Nomenclature of homodetic cyclic peptides produced from ribosomal precursors: An IUPAC task group interim report
Univ Queensland, Inst Mol Biosci, Div Chem & Struct Biol, Brisbane, Qld 4072, Australia..ORCID iD: 0000-0003-0007-6796
Univ Saskatchewan, Coll Agr & Bioresources, Dept Plant Sci, 51 Campus Dr, Saskatoon, SK S7N 5A8, Canada.;Prairie Tide Chem Inc, 102 Melville St, Saskatoon, SK S7J 0R1 5A8, Canada.;Jinan Univ, Dept Food Sci & Engn, Guangdong Saskatchewan Oilseed Joint Lab, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy.
Queen Mary Univ London, Sch Biol & Chem Sci, Mile End Rd, London E1 4NS, England..
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2016 (English)In: Biopolymers, ISSN 0006-3525, E-ISSN 1097-0282, Vol. 106, no 6, 917-924 p.Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

In 2015, an International Union of Pure and Applied Chemistry (IUPAC) Task Group was formed to develop nomenclature recommendations for homodetic cyclic peptides produced from ribosomal precursors. Delegates of the 2015 International Conference on Circular Proteins (ICCP) were presented with the strengths and weaknesses of four published approaches to homodetic cyclic peptide nomenclature, and a summary of the ensuing discussion is presented here. This interim report presents a potentially novel suggestion-the use of Cahn-Ingold-Prelog rules to specify amino acid priority in homodetic peptides for consistent numbering. Indeed, this might be the first extension of the Cahn-Ingold-Prelog rules in five decades. The authors invite interested parties to contact the corresponding author with suggestions for the improvement of the proposed nomenclature; these ideas will be discussed and considered for inclusion in the final report.

Place, publisher, year, edition, pages
2016. Vol. 106, no 6, 917-924 p.
Keyword [en]
CIP rules, cyclic peptides, IUPAC, nomenclature, RiPP
National Category
Medicinal Chemistry Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:uu:diva-317708DOI: 10.1002/bip.22939ISI: 000393465500017PubMedID: 27554762OAI: oai:DiVA.org:uu-317708DiVA: diva2:1082594
Conference
3rd International Conference on Circular Proteins (ICCP), NOV 01-04, 2015, AUSTRALIA
Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-11-29Bibliographically approved

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Göransson, Ulf

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