Nomenclature of homodetic cyclic peptides produced from ribosomal precursors: An IUPAC task group interim report
2016 (English)In: Biopolymers, ISSN 0006-3525, E-ISSN 1097-0282, Vol. 106, no 6, 917-924 p.Article in journal, Meeting abstract (Refereed) Published
In 2015, an International Union of Pure and Applied Chemistry (IUPAC) Task Group was formed to develop nomenclature recommendations for homodetic cyclic peptides produced from ribosomal precursors. Delegates of the 2015 International Conference on Circular Proteins (ICCP) were presented with the strengths and weaknesses of four published approaches to homodetic cyclic peptide nomenclature, and a summary of the ensuing discussion is presented here. This interim report presents a potentially novel suggestion-the use of Cahn-Ingold-Prelog rules to specify amino acid priority in homodetic peptides for consistent numbering. Indeed, this might be the first extension of the Cahn-Ingold-Prelog rules in five decades. The authors invite interested parties to contact the corresponding author with suggestions for the improvement of the proposed nomenclature; these ideas will be discussed and considered for inclusion in the final report.
Place, publisher, year, edition, pages
2016. Vol. 106, no 6, 917-924 p.
CIP rules, cyclic peptides, IUPAC, nomenclature, RiPP
Medicinal Chemistry Cell and Molecular Biology
IdentifiersURN: urn:nbn:se:uu:diva-317708DOI: 10.1002/bip.22939ISI: 000393465500017PubMedID: 27554762OAI: oai:DiVA.org:uu-317708DiVA: diva2:1082594
3rd International Conference on Circular Proteins (ICCP), NOV 01-04, 2015, AUSTRALIA