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Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSG-127
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology, Structural Molecular Biology.
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1995 (English)In: ANTIVIRAL RESEARCH, ISSN 0166-3542, Vol. 28, no 4, 331-342 p.Article in journal (Other scientific) Published
Abstract [en]

A new class of very potent and selective non-nucleoside inhibitors of HIV reverse transcriptase (RT) has recently been identified, The prototype compound trovirdine (LY 300046 HCl) and one analogue, MSG-127, have been studied with respect to inhibition of

Place, publisher, year, edition, pages
1995. Vol. 28, no 4, 331-342 p.
Keyword [en]
human immunodeficiency virus (HIV) reverse transcriptase; mutant; enzyme kinetics; inhibitor; travirdine; STEADY-STATE KINETICS; NONNUCLEOSIDE INHIBITORS; PYRIDINONE DERIVATIVES; HIV-1 REPLICATION; ANTIVIRAL THERAPY; TEMPLATE; TETRAHYDROIMIDAZO<4;5;1-JK><
URN: urn:nbn:se:uu:diva-80352OAI: oai:DiVA.org:uu-80352DiVA: diva2:108266
Addresses: Zhang H, MEDIVIR AB, LUNASTIGEN 7, S-14144 HUDDINGE, SWEDEN. KAROLINSKA INST, DEPT VIROL, S-10521 STOCKHOLM, SWEDEN. BIOMED CTR, DEPT BIOL MOLEC, S-75124 UPPSALA, SWEDEN.Available from: 2008-01-29 Created: 2008-01-29 Last updated: 2011-01-15

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