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Antibody-secreting plasma cells persist for decades in human intestine
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2017 (English)In: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 214, no 2, 309-317 p.Article in journal (Refereed) Published
Abstract [en]

Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19(+) PC subset was dynamically exchanged, whereas of two CD19(-) PC subsets, CD45(+) PCs exhibited little and CD45(-) PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45(-) PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19(-) PC subsets support selection and maintenance of protective PCs for life in human intestine.

Place, publisher, year, edition, pages
NewYork, USA, 2017. Vol. 214, no 2, 309-317 p.
National Category
Biophysics Immunology in the medical area
Research subject
Physics with specialization in Ion Physics
Identifiers
URN: urn:nbn:se:uu:diva-317759DOI: 10.1084/jem.20161590ISI: 000394251400004PubMedID: 28104812OAI: oai:DiVA.org:uu-317759DiVA: diva2:1082765
Projects
The Human Regenerative Map
Funder
Swedish Research CouncilSwedish Cancer SocietyThe Karolinska Institutet's Research FoundationKnut and Alice Wallenberg FoundationTorsten Söderbergs stiftelse
Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-04-03Bibliographically approved

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