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Iron from nanocompounds containing iron and zinc is highly bioavailable in rats without tissue accumulation
Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Human Nutr Lab, CH-8092 Zurich, Switzerland..
Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Physiol & Behav Lab, CH-8603 Schwerzenbach, Switzerland..
Univ Zurich, Vetsuisse Fac, Inst Vet Pathol, CH-8006 Zurich, Switzerland..
Swiss Fed Inst Technol, Dept Mech & Proc Engn, Particle Technol Lab, CH-8092 Zurich, Switzerland..
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2010 (English)In: Nature Nanotechnology, ISSN 1748-3387, E-ISSN 1748-3395, Vol. 5, no 5, 374-380 p.Article in journal (Refereed) Published
Abstract [en]

Effective iron fortification of foods is difficult, because water-soluble compounds that are well absorbed, such as ferrous sulphate (FeSO(4)), often cause unacceptable changes in the colour or taste of foods. Poorly water-soluble compounds, on the other hand, cause fewer sensory changes, but are not well absorbed. Here, we show that poorly water-soluble nanosized Fe and Fe/Zn compounds (specific surface area similar to 190 m(2) g(-1)) made by scalable flame aerosol technology have in vivo iron bioavailability in rats comparable to FeSO(4) and cause less colour change in reactive food matrices than conventional iron fortificants. The addition of Zn to FePO(4) and Mg to Fe/Zn oxide increases Fe absorption from the compounds, and doping with Mg also improves their colour. After feeding rats with nanostructured iron-containing compounds, no stainable Fe was detected in their gut wall, gut-associated lymphatics or other tissues, suggesting no adverse effects. Nanosizing of poorly water-soluble Fe compounds sharply increases their absorption and nutritional value.

Place, publisher, year, edition, pages
2010. Vol. 5, no 5, 374-380 p.
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:uu:diva-317826DOI: 10.1038/NNANO.2010.79ISI: 000278264300018PubMedID: 20418865OAI: oai:DiVA.org:uu-317826DiVA: diva2:1083109
Available from: 2017-03-20 Created: 2017-03-20 Last updated: 2017-03-20

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