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Non-Toxic Dry-Coated Nanosilver for Plasmonic Biosensors
ETH, Dept Mech & Proc Engn, Inst Proc Engn, Particle Technol Lab, CH-8092 Zurich, Switzerland..ORCID iD: 0000-0001-5040-620X
ETH, Mat Res Ctr, Dept Informat Technol & Elect Engn, Lab Biosensors & Bioelect, CH-8092 Zurich, Switzerland..ORCID iD: 0000-0001-7079-2937
ETH, Dept Mech & Proc Engn, Inst Proc Engn, Particle Technol Lab, CH-8092 Zurich, Switzerland..
ETH, Dept Mech & Proc Engn, Inst Proc Engn, Particle Technol Lab, CH-8092 Zurich, Switzerland..ORCID iD: 0000-0001-5625-1536
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2010 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, Vol. 20, no 24, 4250-4257 p.Article in journal (Refereed) Published
Abstract [en]

The plasmonic properties of noble metals facilitate their use for in vivo bio-applications such as targeted drug delivery and cancer cell therapy. Nanosilver is best suited for such applications as it has the lowest plasmonic losses among all such materials in the UV-visible spectrum. Its toxicity, however, can destroy surrounding healthy tissues and thus, hinders its safe use. Here, that toxicity against a model biological system (Escherichia coli) is "cured" or blocked by coating nanosilver hermetically with a about 2 nm thin SiO(2) layer in one-step by a scalable flame aerosol method followed by swirl injection of a silica precursor vapor (hexamethyldisiloxane) without reducing the plasmonic performance of the enclosed or encapsulated silver nanoparticles (20-40 nm in diameter as determined by X-ray diffraction and microscopy). This creates the opportunity to safely use powerful nanosilver for intracellular bio-applications. The label-free biosensing and surface biofunctionalization of these ready-to-use, non-toxic (benign) Ag nanoparticles is presented by measuring the adsorption of bovine serum albumin (BSA) in a model sensing experiment. Furthermore, the silica coating around nanosilver prevents its agglomeration or flocculation (as determined by thermal annealing, optical absorption spectroscopy and microscopy) and thus, enhances its biosensitivity, including bioimaging as determined by dark field illumination.

Place, publisher, year, edition, pages
2010. Vol. 20, no 24, 4250-4257 p.
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:uu:diva-317825DOI: 10.1002/adfm.201000985ISI: 000285393600004PubMedID: 23730266OAI: oai:DiVA.org:uu-317825DiVA: diva2:1083111
Available from: 2017-03-20 Created: 2017-03-20 Last updated: 2017-03-20

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Sotiriou, Georgios A.Sannomiya, TakumiTeleki, AlexandraKrumeich, Frank
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