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Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
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2005 (English)In: Respiratory research (Online), ISSN 1465-993X, Vol. 6, 110- p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Laminins are a group of proteins largely responsible for the anchorage of cells to basement membranes. We hypothesized that altered Laminin chain production in the bronchial mucosa might explain the phenomenon of epithelial cell shedding in asthma. The aim was to characterize the presence of Laminin chains in the SEBM and epithelium in allergic and non-allergic asthmatics.

PATIENTS AND METHODS: Biopsies were taken from the bronchi of 11 patients with allergic and 9 patients with non-allergic asthma and from 7 controls and stained with antibodies against the Laminin (ln) chains alpha1-alpha5, beta1-beta2 and gamma1-gamma2.

RESULTS: Lns-2,-5 and -10 were the main Laminins of SEBM. The layer of ln-10 was thicker in the two asthmatic groups while an increased thickness of lns-2 and -5 was only seen in allergic asthmatics. The ln gamma2-chain, which is only found in ln 5, was exclusively expressed in epithelial cells in association with epithelial injury and in the columnar epithelium of allergic asthmatics.

CONCLUSION: The uncoordinated production of chains of ln-5 in allergic asthma could have a bearing on the poor epithelial cell anchorage in these patients.

Place, publisher, year, edition, pages
2005. Vol. 6, 110- p.
Keyword [en]
Adult, Asthma/complications/*metabolism/*pathology, Cell Adhesion Molecules/*metabolism, Female, Humans, Male, Middle Aged, Research Support; Non-U.S. Gov't, Respiratory Hypersensitivity/complications/*metabolism/*pathology, Respiratory Mucosa/*metabolism/*pathology, Tissue Distribution
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-80514DOI: 10.1186/1465-9921-6-110PubMedID: 16179086OAI: oai:DiVA.org:uu-80514DiVA: diva2:108428
Available from: 2006-05-22 Created: 2006-05-22 Last updated: 2010-12-01Bibliographically approved

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