Body mass index and risk of malignant lymphoma in Scandinavian men and women
2005 (English)In: Journal of the National Cancer Institute, ISSN 0027-8874, E-ISSN 1460-2105, Vol. 97, no 3, 210-218 p.Article in journal (Refereed) Published
BACKGROUND: The incidence of non-Hodgkin lymphoma and prevalence of obesity are increasing globally. A suggested positive association between obesity and risk of non-Hodgkin lymphoma has prompted us to investigate the relationship between body mass index (BMI) and risk of malignant lymphoma subtypes in a population-based case-control study. METHODS: Telephone interviews were conducted with 3055 case patients with non-Hodgkin lymphoma and 618 case patients with Hodgkin lymphoma diagnosed between October 1, 1999, and August 30, 2002, and 3187 population-based control subjects. The interviews assessed current height, normal adult weight, and other possible risk factors. Multivariable odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for risk of lymphoma were estimated by unconditional logistic regression. All statistical tests were two-sided. RESULTS: BMI was not associated with risk of overall non-Hodgkin lymphoma or of Hodgkin lymphoma (for example, comparing the highly obese group [BMI > or =35.0 kg/m2] with the normal-weight group [BMI = 18.5-24.9 kg/m2], OR for risk of non-Hodgkin lymphoma = 0.9, 95% CI = 0.6 to 1.3; P(trend) across all categories of BMI = .27). BMI was also not associated with risk of any non-Hodgkin lymphoma subtype evaluated, although there was some evidence of a positive association with risk of diffuse large B-cell lymphoma (for example, comparing the highly obese group with the normal-weight group, OR for diffuse large B-cell lymphoma = 1.5, 95% CI = 0.9 to 2.4; P(trend) =.05). CONCLUSIONS: Excess weight does not appear to be associated with an increased risk of malignant lymphoma in general, or with a risk of most major lymphoma subtypes. Hence, the growing incidence of obesity is unlikely to be an important contributor to the increasing incidence of non-Hodgkin lymphoma worldwide.
Place, publisher, year, edition, pages
2005. Vol. 97, no 3, 210-218 p.
Adult, Aged, Body Mass Index, Case-Control Studies, Confidence Intervals, Confounding Factors (Epidemiology), Denmark/epidemiology, Female, Humans, Incidence, Logistic Models, Lymphoma; B-Cell/epidemiology, Lymphoma; Large-Cell/epidemiology, Lymphoma; Non-Hodgkin/*epidemiology/etiology, Male, Middle Aged, Obesity/*complications, Odds Ratio, Questionnaires, Research Support; Non-U.S. Gov't, Research Support; U.S. Gov't; P.H.S., Risk Assessment, Risk Factors, Selection Bias, Sweden/epidemiology
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-80560DOI: 10.1093/jnci/dji012PubMedID: 15687364OAI: oai:DiVA.org:uu-80560DiVA: diva2:108474