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Long-term treatment with anti-alpha 4 integrin antibodies aggravates colitis in G alpha i2-deficient mice.
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology. Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Genetics and Pathology.
2005 (English)In: Eur J Immunol, ISSN 0014-2980, Vol. 35, no 8, 2274-83 p.Article in journal (Refereed) Published
Place, publisher, year, edition, pages
2005. Vol. 35, no 8, 2274-83 p.
Keyword [en]
Animals, Antibodies; Blocking/*adverse effects/therapeutic use, Antibodies; Monoclonal/*adverse effects/therapeutic use, Colitis/*immunology/pathology, Colon/drug effects/immunology, Disease Models; Animal, Female, GTP-Binding Protein alpha Subunit; Gi2, GTP-Binding Protein alpha Subunits; Gi-Go/*deficiency/genetics, Immunoglobulin A/blood, Immunoglobulin G/blood, Inflammatory Bowel Diseases/genetics/immunology/*therapy, Integrin alpha4/*immunology, Lymphoid Tissue/drug effects/immunology, Male, Mice, Mice; Inbred C57BL, Mice; Knockout, Proto-Oncogene Proteins/*deficiency/genetics, Research Support; Non-U.S. Gov't, Spleen/drug effects/immunology, T-Lymphocytes/drug effects/immunology, Time Factors
Identifiers
URN: urn:nbn:se:uu:diva-80632PubMedID: 16052630OAI: oai:DiVA.org:uu-80632DiVA: diva2:108546
Available from: 2006-05-18 Created: 2006-05-18 Last updated: 2011-01-11

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