uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Expression of EGFR, HER2, HER3, and HER4 in metastatic squamous cell carcinomas of the oral cavity and base of tongue
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Oncology, Radiology and Clinical Immunology, Biomedical Radiation Sciences. (Earn-Nose-Throat)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Ear-Nose-Throat)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Genetics and Pathology.
Show others and affiliations
2005 (English)In: International Journal of Oncology, ISSN 1019-6439, Vol. 26, no 5, 1177-85 p.Article in journal (Refereed) Published
Abstract [en]

The expressions of all four receptors in the epidermal growth factor receptor family, EGFR. HER2, HER3, and HER4 were evaluated by immunohistochemistry in 19 cases of metastatic squamous cell carcinoma of the oral cavity and base of tongue. EGFR had a similar and high expression in both primary tumours and the corresponding metastases, while the expression in normal epithelium was lower in most cases. HER2 was not expressed to the same extent as EGFR. However, when HER2 was well expressed, it was in most cases expressed to the same extent and intensity in the primary tumours, metastases, and normal epithelium. The expression of HER3 and HER4 varied and was mainly cytoplasmic in all cases studied. No overexpression of HER3 and HER4 in tumours was seen as compared to normal epithelium. In order to further investigate the distribution of HER3, two HER3 expressing cell lines originating from tongue cancer were analysed in vitro, using radiolabelled anti-HER3 antibodies directed to the extracellular domains of the receptor. The results indicated that HER3 was not present in measurable amounts in the cellular membrane. There is a need for improved diagnostics and therapy for the studied type of tumours, e.g. using radiolabelled antibodies or ligands, and EGFR seemed suitable as target since the expression was high, membrane associated and similar in the primary tumours and the corresponding metastases.

Place, publisher, year, edition, pages
2005. Vol. 26, no 5, 1177-85 p.
Keyword [en]
Aged, Aged; 80 and over, Carcinoma; Squamous Cell/*genetics/pathology, Comparative Study, Female, Gene Expression Profiling, Humans, Immunohistochemistry, Ligands, Male, Middle Aged, Receptor; Epidermal Growth Factor/analysis/*biosynthesis, Receptor; erbB-2/analysis/*biosynthesis, Receptor; erbB-3/analysis/*biosynthesis, Research Support; Non-U.S. Gov't, Tongue Neoplasms/*genetics/pathology, Tumor Cells; Cultured
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-80655PubMedID: 15809707OAI: oai:DiVA.org:uu-80655DiVA: diva2:108569
Available from: 2008-02-19 Created: 2008-02-19 Last updated: 2017-12-14Bibliographically approved

Open Access in DiVA

No full text

Other links

PubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=15809707&dopt=Citation

Authority records BETA

Ekberg, ThomasNestor, MarikaEngström, MatsWester, KennethCarlsson, JörgenAnniko, Matti

Search in DiVA

By author/editor
Ekberg, ThomasNestor, MarikaEngström, MatsWester, KennethCarlsson, JörgenAnniko, Matti
By organisation
Department of Surgical SciencesDepartment of Oncology, Radiology and Clinical ImmunologyBiomedical Radiation SciencesDepartment of Genetics and Pathology
In the same journal
International Journal of Oncology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric score

pubmed
urn-nbn
Total: 761 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf