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Pharmacodynamic and pharmacokinetic studies in rats of S-8-(2-furyl)- and R-8-phenyl-2-(di-n-propylamino)tetralin, two novel 5-HT1A receptor agonists in-vitro with different properties in-vivo
Uppsala University.
Uppsala University.
Uppsala University.
Uppsala University.
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1997 (English)In: JOURNAL OF PHARMACY AND PHARMACOLOGY, Vol. 49, no 2, 169-177 p.Other (Other scientific)
Abstract [en]

R- and S-8-(2-Furyl)- and R- and S-8-phenyl-2-(di-n-propylamino)tetralins (R- and S-LY-55 and R- and S-LY-49, respectively), novel enantiopure dipropylaminotetralins, have been screened as 5-HT1A receptor ligands. All had nanomolar affinities for 5-HT1A

Place, publisher, year, pages
ROYAL PHARMACEUTICAL SOC GREAT BRITAIN , 1997. Vol. 49, no 2, 169-177 p.
Keyword [en]
BLOOD-BRAIN-BARRIER; ADENYLATE-CYCLASE; P-GLYCOPROTEIN; INHIBITION; 5-HYDROXYTRYPTAMINE; INVIVO; 2-(DIPROPYLAMINO)TETRALIN; PHARMACOLOGY; DERIVATIVES; ANTAGONIST
Identifiers
URN: urn:nbn:se:uu:diva-80660OAI: oai:DiVA.org:uu-80660DiVA: diva2:108574
Note
Addresses: UPPSALA UNIV, DEPT PSYCHIAT ULLERAKER, S-75017 UPPSALA, SWEDEN. UNIV UPPSALA, DEPT ORGAN PHARMACEUT CHEM, S-75123 UPPSALA, SWEDEN. UNIV ARIZONA, COLL PHARM, DEPT PHARMACOL & TOXICOL, TUCSON, AZ 85721.Available from: 2008-10-17 Created: 2008-10-17

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