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Comparison between semiquantitative and quantitative methods for the assessment of knee synovitis in osteoarthritis using non-enhanced and gadolinium-enhanced MRI
Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, 820 Harrison Ave,FGH Bldg,3rd Floor, Boston, MA 02118 USA.;Univ Paris 06, St Antoine Hosp, Dept Radiol, Paris, France..
Boston Univ, Sch Med, Dept Radiol, Quantitat Imaging Ctr, 820 Harrison Ave,FGH Bldg,3rd Floor, Boston, MA 02118 USA.;Univ Erlangen Nurnberg, Dept Radiol, Erlangen, Germany..
Harvard Med Sch, Dana Farber Canc Inst, Boston, MA USA..
Pfizer Neurosci, Cambridge, MA USA.;AstraZeneca, London, England..
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2017 (English)In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 25, no 2, 267-271 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To compare different semiquantitative and quantitative methods using both non-enhanced and gadolinium-enhanced MRI techniques for the assessment of synovitis in knee osteoarthritis (OA). Methods: Knees with end-stage clinical OA in patients undergoing total knee replacement surgery were included in this cross-sectional study. MRI was performed on all knees. Standard non-enhanced and gadolinium-enhanced sequences were acquired. Using non-enhanced MRI, we semiquantitatively assessed two features widely used as surrogates for synovitis: effusion-synovitis and Hoffa-synovitis. Using gadolinium-enhanced sequences, we semiquantitatively assessed synovial thickness. We quantitatively evaluated the total synovial volume on the gadolinium-enhanced sequences as well. We assessed the correlations of effusion-synovitis and Hoffa-synovitis with synovial thickness and volume, applying Spearman correlation analysis. The diagnostic performance of both synovitis features on non-enhanced MRI was assessed using synovial thickness on gadolinium-enhanced MRI as the reference. Results: A total of 104 subjects (one knee per subject) were included. Correlations of effusion-synovitis with synovial thickness and volume were r = 0.41 and r = 0.43 (P < .001) r = 0.32 and r = 0.39 (P < .0001). Conclusion: Using synovial thickness assessed on gadolinium-enhanced sequences as the reference, effusion-synovitis showed superior correlations and sensitivity. Effusion-synovitis should be preferred over Hoffa-synovitis as a surrogate marker for synovial thickening, in studies of knee OA for which gadolinium-enhanced sequences are not available.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD , 2017. Vol. 25, no 2, 267-271 p.
Keyword [en]
Osteoarthritis, Knee, Synovitis, Magnetic resonance imaging
National Category
Orthopedics Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:uu:diva-318601DOI: 10.1016/j.joca.2016.09.016ISI: 000393529500012PubMedID: 27697506OAI: oai:DiVA.org:uu-318601DiVA: diva2:1086014
Available from: 2017-03-31 Created: 2017-03-31 Last updated: 2017-03-31Bibliographically approved

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