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Optimisation of chromatographic separations by use of a chromatographic response function, empirical modelling and multivariate analysis
Uppsala University.
Uppsala University.
Uppsala University.
1997 (English)In: CHROMATOGRAPHIA, Vol. 44, no 1-2, 74-80 p.Other (Other scientific)
Abstract [en]

The chiral separation of the drug substance R,S-oxybutynin chloride on a reversed phase HPLC system has been optimised by use of empirical modelling and multivariate analysis. The separation was characterised by a new chromatographic response function de

Place, publisher, year, edition, pages
VIEWEG , 1997. Vol. 44, no 1-2, 74-80 p.
Keyword [en]
column liquid chromatography; chiral separation; optimisation; multiple linear regression; neural networks; PERFORMANCE LIQUID-CHROMATOGRAPHY; NEURAL NETWORKS; OPTIMIZATION; INFORMATION; ENANTIOMERS; CRITERIA; COLUMN
URN: urn:nbn:se:uu:diva-80747OAI: oai:DiVA.org:uu-80747DiVA: diva2:108661
Addresses: UNIV UPPSALA, DEPT ANALYT CHEM, S-75121 UPPSALA, SWEDEN. PHARMACIA & UPJOHN INC, DEPT ANALYT CHEM, S-75182 UPPSALA, SWEDEN.Available from: 2008-10-17 Created: 2008-10-17

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