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Expression of sex steroid hormone receptors in human skeletal muscle during the menstrual cycle
Karolinska Inst, Div Physiotherapy, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Karolinska Inst, Novum, Dept Biosci & Nutr, Huddinge, Sweden..
Karolinska Inst, Div Physiotherapy, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden.;St Erik Primary Hlth Care Ctr, Acad Primary Hlth Care Ctr, Stockholm, Sweden..
Karolinska Inst, Novum, Dept Biosci & Nutr, Huddinge, Sweden..
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2017 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 219, no 2, 486-493 p.Article in journal (Refereed) Published
Abstract [en]

Aim: Variations in sex hormone levels during the menstrual cycle may affect neuromuscular performance and the risk of sustaining musculoskeletal injury in women. The aim of this study was to investigate mRNA and protein levels for sex steroid hormone receptors in skeletal muscle in three distinct phases of the menstrual cycle. Methods: Fifteen, healthy women with regular menstrual cycles participated in the study. Muscle biopsies from the vastus lateralis were obtained in three hormonally verified phases of the menstrual cycle for each individual, that is the follicular phase, the ovulatory phase and the luteal phase. mRNA and protein levels of oestrogen (ER and ER), progesterone (PR) and androgen (AR) receptors were analysed. Results: There was an overall significant variation in mRNA and protein levels of ER and PR across the menstrual cycle. mRNA and protein levels of ER were highest in the follicular phase when oestradiol levels were low, whereas protein levels of PR were highest in the luteal phase when progesterone levels were high. mRNA levels of PR were highest in the ovulatory phase. No significant variation in AR levels was detected across the menstrual cycle. ER levels were very low in all three phases of the menstrual cycle. Conclusion: Significant variations in mRNA and protein levels of ER and PR were detected in skeletal muscle during three confirmed phases of the menstrual cycle. These results may have an impact on effects of muscular training and sports injuries in women.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2017. Vol. 219, no 2, 486-493 p.
Keyword [en]
androgen receptor, oestrogen receptor-alpha, oestrogen receptor-beta, progesterone receptor, skeletal muscle
National Category
Physiology
Identifiers
URN: urn:nbn:se:uu:diva-319102DOI: 10.1111/apha.12757ISI: 000393912000013PubMedID: 27438889OAI: oai:DiVA.org:uu-319102DiVA: diva2:1086681
Available from: 2017-04-03 Created: 2017-04-03 Last updated: 2017-04-03Bibliographically approved

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