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Cytotoxic Effects Of The Red Sea Soft Coral Sarcophyton Trocheliophorum
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Medicinal Chemistry, Division of Pharmacognosy. Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia.;Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm 32512, Egypt..
Univ Jeddah, Fac Sci & Arts, Dept Biol, Khulais, Saudi Arabia..
Univ Jeddah, Fac Sci & Arts, Dept Biol, Khulais, Saudi Arabia..
Int Islamic Univ Malaysia, Fac Pharm, Dept Pharmaceut Chem, Kuantan 25200, Pahang, Malaysia..
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2016 (English)In: ACTA POLONIAE PHARMACEUTICA, ISSN 0001-6837, Vol. 73, no 6, 1587-1592 p.Article in journal (Refereed) Published
Abstract [en]

The present study describes the in vitro cytotoxic effects of soft coral (Sarcophyton trocheliophorum). Soft corals of genus Sarcophyton were reported to contain compounds that arc active against brine shrimp and promote paclitaxel cytotoxicity in the human colon cancer Caco-2 cell line. The a-hexane extract of the soft coral Sarcophyton trocheliophorum induced significant dose-dependent toxicity (LC50 96.7 ppm) compared with ethyl acetate (LC50 120 ppm). We reported the most active cytotoxic level to be correspondence to LC50 values of 20.2, 59.2 ppm and 18.9 and 26 ppm. Accordingly, bio-assay guided fractionation was conducted to identify the bioactive compounds. Arachidonic acid. eicosapentaenoic acid and docosahexaenoic acid were characterized based on GC-MS analyses. Our results demonstrate the value of marine products as a natural source of medicinally interesting cytotoxic compounds.

Place, publisher, year, edition, pages
POLSKIE TOWARZYSTWO FARMACEUTYCZNE , 2016. Vol. 73, no 6, 1587-1592 p.
Keyword [en]
cytotoxic activity, GC-MS, Sarcophyton trocheliophorum, soft coral, unsaturated fatty acid
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-319409ISI: 000395231300021OAI: oai:DiVA.org:uu-319409DiVA: diva2:1086816
Available from: 2017-04-04 Created: 2017-04-04 Last updated: 2017-04-04Bibliographically approved

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El-Seedi, Hesham R.
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CiteExportLink to record
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